mortality/aging
• median survival is 2.5 months
|
liver/biliary system
• mice exhibit apoptosis in the liver that is restricted to hepatocytes
|
• mice exhibit prominent liver lesions at 10 weeks with large necrotic lesions
|
• the number of proliferating hepatocyte is decreased (74.2+/-9.1 compare to 95.2+/-3.7 in wild-type mice)
|
growth/size/body
• at 5 weeks of age
|
cellular
• mice exhibit apoptosis in the liver that is restricted to hepatocytes
|
• mice exhibit prominent liver lesions at 10 weeks with large necrotic lesions
|
• the number of proliferating hepatocyte is decreased (74.2+/-9.1 compare to 95.2+/-3.7 in wild-type mice)
|