Mouse Genome Informatics
ht
    Krastm3Tyj/Kras+
involves: 129S2/SvPas * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• Background Sensitivity: mean age at death is ~200 days

tumorigenesis
• all animals at time of death/sacrifice have extensive tumor burden
• mice display a more rapid tumor phenotype than Krastm2Tyj heterozygotes
• Background Sensitivity: animals are prone to skin papillomas (seen in ~20% of animals); tumors typically arising on ears and snout are predominantly pedunculated and show limited tendency to progress to squamous cell carcinoma
• Background Sensitivity: animals are prone to thymic lymphomas (seen in ~40% of animals)
• 100% of animals show multifocal tumors at time of death/sacrifice
• tumors are detectable at 1 week of age as small pleural nodules; multiplicity and size of tumors increases with age, and ultimately result in respiratory distress and death
• tumors range from mild hyperplasia/dysplasia to overt carcinoma; small lesions consist of hyperplastic alveolar epithelium
• in older mice, infrequent metastases to thoracic lymph nodes, the kidney and other visceral organs
• as lesions enlarge, they form small alveolar adenomas; some show areas of glandular differentiation
• 5-10% of tumors have features of well-differentiated human papillary adenocarcinoma

digestive/alimentary system
• mutants have multiple aberrant crypt foci (ACF) of the colon

endocrine/exocrine glands
• mutants have multiple aberrant crypt foci (ACF) of the colon

integument
• Background Sensitivity: animals are prone to skin papillomas (seen in ~20% of animals); tumors typically arising on ears and snout are predominantly pedunculated and show limited tendency to progress to squamous cell carcinoma

Mouse Models of Human Disease
OMIM IDRef(s)
Lung Cancer 211980 J:68981