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Phenotypes Associated with This Genotype
Genotype
MGI:3769345
Allelic
Composition
Jak3tm1Ljb/Jak3tm1Ljb
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak3tm1Ljb mutation (1 available); any Jak3 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increase in the ratio of CD4+ to CD8+ cells (J:128694)
• increase in the ratio of CD4+ to CD8+ cells (J:128694)
• increase in the number of myeloid progenitor cells in the peripheral blood and bone marrow (J:56629)
• increase in the number of myeloid progenitor cells in the peripheral blood and bone marrow (J:56629)
• large increase in the number of cells classified as myeloid or premonocytic (J:56629)
• large increase in the number of cells classified as myeloid or premonocytic (J:56629)
• the proportion of pro-T cells is increased about 3-fold and fewer cells in transition between pre-T and late pre-T cell stages are found (J:64861)
• both pro-T and pre-T cells have increased CD25 expression (J:64861)
• about a 2-fold increase in apoptotic thymocytes is seen from E14 - E17 (J:64861)
• intrathymically injected bone marrow cells show extremely limited ability to reconstitute T cell development especially when in competition with heterozygous or wild-type cells (J:64861)
• most intrathymically injected cells arrest at the CD44+ CD25- double negativeprogenitor cell stage (J:64861)
• from E15 - E17, T cell maturation appears to be delayed by about 1 day compared to age-matched heterozygous littermates (J:64861)
• however, by E18 T cell maturation in homozygous mice has caught up to that of their heterozygous littermates (J:64861)
• the proportion of pro-T cells is increased about 3-fold and fewer cells in transition between pre-T and late pre-T cell stages are found (J:64861)
• both pro-T and pre-T cells have increased CD25 expression (J:64861)
• about a 2-fold increase in apoptotic thymocytes is seen from E14 - E17 (J:64861)
• intrathymically injected bone marrow cells show extremely limited ability to reconstitute T cell development especially when in competition with heterozygous or wild-type cells (J:64861)
• most intrathymically injected cells arrest at the CD44+ CD25- double negativeprogenitor cell stage (J:64861)
• from E15 - E17, T cell maturation appears to be delayed by about 1 day compared to age-matched heterozygous littermates (J:64861)
• however, by E18 T cell maturation in homozygous mice has caught up to that of their heterozygous littermates (J:64861)
• lymphopenia is seen in peripheral and bone marrow smears (J:56629)
• at 6-12 months of age, lymphocyte numbers in whole blood suspensions are decreased (J:56629)
• lymphopenia is seen in peripheral and bone marrow smears (J:56629)
• at 6-12 months of age, lymphocyte numbers in whole blood suspensions are decreased (J:56629)
• in adult mice, there is about a 20-fold reduction in thymocyte numbers (J:64861)
• at E14 - E15, thymocytes are virtually undetectable (J:64861)
• at E14 only about 200 Thy+ cells are present in the thymus compared to around 20,000 in age-matched heterozygous littermates (J:64861)
• despite the deficit in progenitors, the rate of thymocyte expansion between E14 and E18 and differentiation of thymic progenitors into pro-T cells are similar to that of heterozygous littermates (J:64861)
• in adult mice, there is about a 20-fold reduction in thymocyte numbers (J:64861)
• at E14 - E15, thymocytes are virtually undetectable (J:64861)
• at E14 only about 200 Thy+ cells are present in the thymus compared to around 20,000 in age-matched heterozygous littermates (J:64861)
• despite the deficit in progenitors, the rate of thymocyte expansion between E14 and E18 and differentiation of thymic progenitors into pro-T cells are similar to that of heterozygous littermates (J:64861)
• at 6-12 months of age, a profound increase in large granular cells is seen in the peripheral blood and spleen (J:56629)
• these large granular cells consist of 2 populations; cells of the neutrophilic lineage and cells of the monocytic lineage (J:56629)
• at 6-12 months of age, a profound increase in large granular cells is seen in the peripheral blood and spleen (J:56629)
• these large granular cells consist of 2 populations; cells of the neutrophilic lineage and cells of the monocytic lineage (J:56629)
• significantly higher numbers of both segmented and band neutrophils (J:56629)
• significantly higher numbers of both segmented and band neutrophils (J:56629)
• at 6 - 12 months of age in the bone marrow and spleen (J:56629)
• at 6 - 12 months of age in the bone marrow and spleen (J:56629)
• the general architecture of the spleen is severely disrupted (J:56629)
• the general architecture of the spleen is severely disrupted (J:56629)
• may be seen in some mice by as early as 4 months of age (J:56629)
• seen in all mice over 5 months of age (J:56629)
• may be seen in some mice by as early as 4 months of age (J:56629)
• seen in all mice over 5 months of age (J:56629)
• the white pulp is replaced with a collection of large cells with euchromatic nuclei that are CD3+ (J:56629)
• numerous megakaryoctes are present (J:56629)
• the white pulp is replaced with a collection of large cells with euchromatic nuclei that are CD3+ (J:56629)
• numerous megakaryoctes are present (J:56629)
• thymocytes produce less IL12 and IL13 in response to anti-CD3 plus anti-CD28-stimulation compared to wild-type controls (J:128694)
• splenic T cells secrete less IL12 in response to T cell receptor plus CD28 stimulation (J:128694)
• thymocytes produce less IL12 and IL13 in response to anti-CD3 plus anti-CD28-stimulation compared to wild-type controls (J:128694)
• splenic T cells secrete less IL12 in response to T cell receptor plus CD28 stimulation (J:128694)
• CD4+ cells that are present show an activated phenotype (J:56629)
• CD4+ cells that are present show an activated phenotype (J:56629)
• CD4+ T cells resemble activated or memory T cells (J:128694)
• CD4+ T cells resemble activated or memory T cells (J:128694)
• decrease in thymocyte proliferation in response to CD3 plus CD28 stimulation compared to wild-type (J:128694)
• the proliferative response of splenic T cells in response to T cell receptor plus CD28 stimulation is virtually absent (J:128694)
• decrease in thymocyte proliferation in response to CD3 plus CD28 stimulation compared to wild-type (J:128694)
• the proliferative response of splenic T cells in response to T cell receptor plus CD28 stimulation is virtually absent (J:128694)
• widespread infiltration of the lungs, kidneys, and liver with mononuclear cells (J:56629)
• widespread infiltration of the lungs, kidneys, and liver with mononuclear cells (J:56629)

hematopoietic system
• increase in the ratio of CD4+ to CD8+ cells (J:128694)
• increase in the ratio of CD4+ to CD8+ cells (J:128694)
• slight decrease in the number of erythroid progenitors in the bone marrow (J:56629)
• slight decrease in the number of erythroid progenitors in the bone marrow (J:56629)
• increase in the number of myeloid progenitor cells in the peripheral blood and bone marrow (J:56629)
• increase in the number of myeloid progenitor cells in the peripheral blood and bone marrow (J:56629)
• large increase in the number of cells classified as myeloid or premonocytic (J:56629)
• large increase in the number of cells classified as myeloid or premonocytic (J:56629)
• the proportion of pro-T cells is increased about 3-fold and fewer cells in transition between pre-T and late pre-T cell stages are found (J:64861)
• both pro-T and pre-T cells have increased CD25 expression (J:64861)
• about a 2-fold increase in apoptotic thymocytes is seen from E14 - E17 (J:64861)
• intrathymically injected bone marrow cells show extremely limited ability to reconstitute T cell development especially when in competition with heterozygous or wild-type cells (J:64861)
• most intrathymically injected cells arrest at the CD44+ CD25- double negativeprogenitor cell stage (J:64861)
• from E15 - E17, T cell maturation appears to be delayed by about 1 day compared to age-matched heterozygous littermates (J:64861)
• however, by E18 T cell maturation in homozygous mice has caught up to that of their heterozygous littermates (J:64861)
• the proportion of pro-T cells is increased about 3-fold and fewer cells in transition between pre-T and late pre-T cell stages are found (J:64861)
• both pro-T and pre-T cells have increased CD25 expression (J:64861)
• about a 2-fold increase in apoptotic thymocytes is seen from E14 - E17 (J:64861)
• intrathymically injected bone marrow cells show extremely limited ability to reconstitute T cell development especially when in competition with heterozygous or wild-type cells (J:64861)
• most intrathymically injected cells arrest at the CD44+ CD25- double negativeprogenitor cell stage (J:64861)
• from E15 - E17, T cell maturation appears to be delayed by about 1 day compared to age-matched heterozygous littermates (J:64861)
• however, by E18 T cell maturation in homozygous mice has caught up to that of their heterozygous littermates (J:64861)
• lymphopenia is seen in peripheral and bone marrow smears (J:56629)
• at 6-12 months of age, lymphocyte numbers in whole blood suspensions are decreased (J:56629)
• lymphopenia is seen in peripheral and bone marrow smears (J:56629)
• at 6-12 months of age, lymphocyte numbers in whole blood suspensions are decreased (J:56629)
• in adult mice, there is about a 20-fold reduction in thymocyte numbers (J:64861)
• at E14 - E15, thymocytes are virtually undetectable (J:64861)
• at E14 only about 200 Thy+ cells are present in the thymus compared to around 20,000 in age-matched heterozygous littermates (J:64861)
• despite the deficit in progenitors, the rate of thymocyte expansion between E14 and E18 and differentiation of thymic progenitors into pro-T cells are similar to that of heterozygous littermates (J:64861)
• in adult mice, there is about a 20-fold reduction in thymocyte numbers (J:64861)
• at E14 - E15, thymocytes are virtually undetectable (J:64861)
• at E14 only about 200 Thy+ cells are present in the thymus compared to around 20,000 in age-matched heterozygous littermates (J:64861)
• despite the deficit in progenitors, the rate of thymocyte expansion between E14 and E18 and differentiation of thymic progenitors into pro-T cells are similar to that of heterozygous littermates (J:64861)
• at 6-12 months of age, a profound increase in large granular cells is seen in the peripheral blood and spleen (J:56629)
• these large granular cells consist of 2 populations; cells of the neutrophilic lineage and cells of the monocytic lineage (J:56629)
• at 6-12 months of age, a profound increase in large granular cells is seen in the peripheral blood and spleen (J:56629)
• these large granular cells consist of 2 populations; cells of the neutrophilic lineage and cells of the monocytic lineage (J:56629)
• significantly higher numbers of both segmented and band neutrophils (J:56629)
• significantly higher numbers of both segmented and band neutrophils (J:56629)
• at 6 - 12 months of age in the bone marrow and spleen (J:56629)
• at 6 - 12 months of age in the bone marrow and spleen (J:56629)
• the general architecture of the spleen is severely disrupted (J:56629)
• the general architecture of the spleen is severely disrupted (J:56629)
• may be seen in some mice by as early as 4 months of age (J:56629)
• seen in all mice over 5 months of age (J:56629)
• may be seen in some mice by as early as 4 months of age (J:56629)
• seen in all mice over 5 months of age (J:56629)
• the white pulp is replaced with a collection of large cells with euchromatic nuclei that are CD3+ (J:56629)
• numerous megakaryoctes are present (J:56629)
• the white pulp is replaced with a collection of large cells with euchromatic nuclei that are CD3+ (J:56629)
• numerous megakaryoctes are present (J:56629)
• thymocytes produce less IL12 and IL13 in response to anti-CD3 plus anti-CD28-stimulation compared to wild-type controls (J:128694)
• splenic T cells secrete less IL12 in response to T cell receptor plus CD28 stimulation (J:128694)
• thymocytes produce less IL12 and IL13 in response to anti-CD3 plus anti-CD28-stimulation compared to wild-type controls (J:128694)
• splenic T cells secrete less IL12 in response to T cell receptor plus CD28 stimulation (J:128694)
• CD4+ cells that are present show an activated phenotype (J:56629)
• CD4+ cells that are present show an activated phenotype (J:56629)
• CD4+ T cells resemble activated or memory T cells (J:128694)
• CD4+ T cells resemble activated or memory T cells (J:128694)
• decrease in thymocyte proliferation in response to CD3 plus CD28 stimulation compared to wild-type (J:128694)
• the proliferative response of splenic T cells in response to T cell receptor plus CD28 stimulation is virtually absent (J:128694)
• decrease in thymocyte proliferation in response to CD3 plus CD28 stimulation compared to wild-type (J:128694)
• the proliferative response of splenic T cells in response to T cell receptor plus CD28 stimulation is virtually absent (J:128694)

endocrine/exocrine glands
• increase in the ratio of CD4+ to CD8+ cells (J:128694)
• increase in the ratio of CD4+ to CD8+ cells (J:128694)
• in adult mice, there is about a 20-fold reduction in thymocyte numbers (J:64861)
• at E14 - E15, thymocytes are virtually undetectable (J:64861)
• at E14 only about 200 Thy+ cells are present in the thymus compared to around 20,000 in age-matched heterozygous littermates (J:64861)
• despite the deficit in progenitors, the rate of thymocyte expansion between E14 and E18 and differentiation of thymic progenitors into pro-T cells are similar to that of heterozygous littermates (J:64861)
• in adult mice, there is about a 20-fold reduction in thymocyte numbers (J:64861)
• at E14 - E15, thymocytes are virtually undetectable (J:64861)
• at E14 only about 200 Thy+ cells are present in the thymus compared to around 20,000 in age-matched heterozygous littermates (J:64861)
• despite the deficit in progenitors, the rate of thymocyte expansion between E14 and E18 and differentiation of thymic progenitors into pro-T cells are similar to that of heterozygous littermates (J:64861)


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory