Phenotypes Associated with This Genotype

Genotype
MGI:3768911

• Allelic Composition: Dmc1^Mei11/Dmc1⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Histopathology of Dmc1^Mei11/Dmc⁺ mouse testes

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:122037 )

♀ • depletion of primordial and primary follicle pools in 6-week old females compared to wild-type

reproductive system

abnormal ovarian follicle morphology ( J:122037 )

♀ • depletion of primordial and primary follicle pools in 6-week old females compared to wild-type

abnormal female meiosis ( J:122037 )

♀ • oocytes exhibit synaptic defects, core fragmentation and persistent double stranded breaks

arrest of male meiosis ( J:122037 )

♂ • Background Sensitivity: the vast majority of seminiferous tubules are arrested at epithelial stage IV, however observe rare seminiferous tubules containing mid-pachynema spermatocytes and postmeiotic round and elongating spermatids, indicating that severity is somewhat less on a C57BL/6J background than on a C3HeB/FeJ background

male infertility ( J:122037 )

♂