Analysis Tools
mortality/aging
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• mice die suddenly within a few days after weaning (average lifespan ~23.8 days); even if mutants are left with the mother, survival is <30 days
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growth/size/body
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• at P8, triple mutants weigh less than their littermates and at P20 are ~50% of wild-type littermates
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nervous system
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• degenerating neurons are found in brain and spinal cord of mutants
• mice show accelerated degeneration relative to Dnajc5-null animals at 10 days of age
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