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Phenotypes Associated with This Genotype
Genotype
MGI:3767713
Allelic
Composition
Serpini2pq/Serpini2pq
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpini2pq mutation (0 available); any Serpini2 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Runted size and acinar cell loss in Serpini2pq/Serpini2pq mice

mortality/aging
• typically live 2-7 months; lifespan increases when mutants are housed in sterile cages with acidified water or when mutants are supplemented with pancreatic enzymes (J:115744)
• typically live 2-7 months; lifespan increases when mutants are housed in sterile cages with acidified water or when mutants are supplemented with pancreatic enzymes (J:115744)

growth/size/body
• homozygotes are on average 1/3 the weight of wild-type (J:115744)
• homozygotes are on average 1/3 the weight of wild-type (J:115744)
• due to exocrine pancreatic insufficiency (J:115744)
• due to exocrine pancreatic insufficiency (J:115744)

endocrine/exocrine glands
• loss of acinar cells, due to progressive apoptosis, in the exocrine pancreas between 1 and 3 weeks of age such that by 3 weeks of age, mutants have only about 1/2 the number of pancreatic acinar cells, despite normal appearance of ductal and endocrine islet cells (J:115744)
• loss of acinar cells, due to progressive apoptosis, in the exocrine pancreas between 1 and 3 weeks of age such that by 3 weeks of age, mutants have only about 1/2 the number of pancreatic acinar cells, despite normal appearance of ductal and endocrine islet cells (J:115744)
• acinar cells exhibit a reduction in size and number of dense zymogen granules in the cytoplasm and a lack of dense material within the ductal network (J:115744)
• acinar cells exhibit a reduction in size and number of dense zymogen granules in the cytoplasm and a lack of dense material within the ductal network (J:115744)
• pancreatic insufficiency is characterized by loss of pancreatic acinar cells resulting in mice that are unable to absorb nutrients from the diet, stunting growth and giving rise to immunological anomalies (J:115744)
• pancreatic enzyme diet supplementation or BAC transgene rescue restores size, weight, viability and immune cell numbers (J:115744)
• pancreatic insufficiency is characterized by loss of pancreatic acinar cells resulting in mice that are unable to absorb nutrients from the diet, stunting growth and giving rise to immunological anomalies (J:115744)
• pancreatic enzyme diet supplementation or BAC transgene rescue restores size, weight, viability and immune cell numbers (J:115744)
• thymus is about 4-fold smaller than in wild-type at 8 weeks of age (J:115744)
• despite the reduction in thymic size, thymocyte profile is normal, with cells progressing from the most immature double negative cells to double positive and single-positive mature cells with no block at any stage; thymic development is not blocked (J:115744)
• thymus is about 4-fold smaller than in wild-type at 8 weeks of age (J:115744)
• despite the reduction in thymic size, thymocyte profile is normal, with cells progressing from the most immature double negative cells to double positive and single-positive mature cells with no block at any stage; thymic development is not blocked (J:115744)
• reduction in thymic cellularity by 21 and 28 days of age (J:115744)
• reduction in thymic cellularity by 21 and 28 days of age (J:115744)
• thymocyte numbers are severely reduced, 10-20-fold (J:115744)
• thymocyte numbers are severely reduced, 10-20-fold (J:115744)

hematopoietic system
• thymus is about 4-fold smaller than in wild-type at 8 weeks of age (J:115744)
• despite the reduction in thymic size, thymocyte profile is normal, with cells progressing from the most immature double negative cells to double positive and single-positive mature cells with no block at any stage; thymic development is not blocked (J:115744)
• thymus is about 4-fold smaller than in wild-type at 8 weeks of age (J:115744)
• despite the reduction in thymic size, thymocyte profile is normal, with cells progressing from the most immature double negative cells to double positive and single-positive mature cells with no block at any stage; thymic development is not blocked (J:115744)
• reduction in thymic cellularity by 21 and 28 days of age (J:115744)
• reduction in thymic cellularity by 21 and 28 days of age (J:115744)
• within the CD43+ fraction, pro-B cells express lower levels of CD24, demonstrating that block occurs between the pre-proB and early pro-B cell stage (J:115744)
• within the CD43+ fraction, pro-B cells express lower levels of CD24, demonstrating that block occurs between the pre-proB and early pro-B cell stage (J:115744)
• reduction in bone marrow cellularity by 21 and 28 days of age (J:115744)
• decrease in early B cell progenitors in the bone marrow (J:115744)
• reduction in bone marrow cellularity by 21 and 28 days of age (J:115744)
• decrease in early B cell progenitors in the bone marrow (J:115744)
• spleens at 3-4 weeks of age show a reduction in lymphoctye numbers (J:115744)
• spleens at 3-4 weeks of age show a reduction in lymphoctye numbers (J:115744)
• B cell numbers are reduced more than 10-fold in spleens at 3-4 weeks of age (J:115744)
• B cell numbers are reduced more than 10-fold in spleens at 3-4 weeks of age (J:115744)
• in the spleen, reduced numbers of the most immature population of B cells (IgM+IgD-) is seen (J:115744)
• expression of IgM on immature cells is lower (J:115744)
• in the spleen, reduced numbers of the most immature population of B cells (IgM+IgD-) is seen (J:115744)
• expression of IgM on immature cells is lower (J:115744)
• decrease in mature T cells (J:115744)
• T cell numbers are reduced about 5-fold in the spleen at 3-4 weeks of age (J:115744)
• decrease in mature T cells (J:115744)
• T cell numbers are reduced about 5-fold in the spleen at 3-4 weeks of age (J:115744)
• thymocyte numbers are severely reduced, 10-20-fold (J:115744)
• thymocyte numbers are severely reduced, 10-20-fold (J:115744)
• compared to wild-type, pre-B cells manifest a higher percentage of B220+IgM-CD43+ cells, indicating a partial block in B cell development prior to the pre-B cell stage; block becomes more apparent as mutants age (J:115744)
• compared to wild-type, pre-B cells manifest a higher percentage of B220+IgM-CD43+ cells, indicating a partial block in B cell development prior to the pre-B cell stage; block becomes more apparent as mutants age (J:115744)
• spleen is about 4-fold smaller than in wild-type at 8 weeks of age (J:115744)
• spleen is about 4-fold smaller than in wild-type at 8 weeks of age (J:115744)
• reduction in splenic cellularity by 21 and 28 days of age (J:115744)
• spleens at 3-4 weeks of age show a reduction in lymphocyte numbers, with T cell numbers reduced about 5-fold and B cell numbers reduced more than 10-fold (J:115744)
• reduction in splenic cellularity by 21 and 28 days of age (J:115744)
• spleens at 3-4 weeks of age show a reduction in lymphocyte numbers, with T cell numbers reduced about 5-fold and B cell numbers reduced more than 10-fold (J:115744)

immune system
• thymus is about 4-fold smaller than in wild-type at 8 weeks of age (J:115744)
• despite the reduction in thymic size, thymocyte profile is normal, with cells progressing from the most immature double negative cells to double positive and single-positive mature cells with no block at any stage; thymic development is not blocked (J:115744)
• thymus is about 4-fold smaller than in wild-type at 8 weeks of age (J:115744)
• despite the reduction in thymic size, thymocyte profile is normal, with cells progressing from the most immature double negative cells to double positive and single-positive mature cells with no block at any stage; thymic development is not blocked (J:115744)
• reduction in thymic cellularity by 21 and 28 days of age (J:115744)
• reduction in thymic cellularity by 21 and 28 days of age (J:115744)
• within the CD43+ fraction, pro-B cells express lower levels of CD24, demonstrating that block occurs between the pre-proB and early pro-B cell stage (J:115744)
• within the CD43+ fraction, pro-B cells express lower levels of CD24, demonstrating that block occurs between the pre-proB and early pro-B cell stage (J:115744)
• spleens at 3-4 weeks of age show a reduction in lymphoctye numbers (J:115744)
• spleens at 3-4 weeks of age show a reduction in lymphoctye numbers (J:115744)
• B cell numbers are reduced more than 10-fold in spleens at 3-4 weeks of age (J:115744)
• B cell numbers are reduced more than 10-fold in spleens at 3-4 weeks of age (J:115744)
• in the spleen, reduced numbers of the most immature population of B cells (IgM+IgD-) is seen (J:115744)
• expression of IgM on immature cells is lower (J:115744)
• in the spleen, reduced numbers of the most immature population of B cells (IgM+IgD-) is seen (J:115744)
• expression of IgM on immature cells is lower (J:115744)
• decrease in mature T cells (J:115744)
• T cell numbers are reduced about 5-fold in the spleen at 3-4 weeks of age (J:115744)
• decrease in mature T cells (J:115744)
• T cell numbers are reduced about 5-fold in the spleen at 3-4 weeks of age (J:115744)
• thymocyte numbers are severely reduced, 10-20-fold (J:115744)
• thymocyte numbers are severely reduced, 10-20-fold (J:115744)
• compared to wild-type, pre-B cells manifest a higher percentage of B220+IgM-CD43+ cells, indicating a partial block in B cell development prior to the pre-B cell stage; block becomes more apparent as mutants age (J:115744)
• compared to wild-type, pre-B cells manifest a higher percentage of B220+IgM-CD43+ cells, indicating a partial block in B cell development prior to the pre-B cell stage; block becomes more apparent as mutants age (J:115744)
• spleen is about 4-fold smaller than in wild-type at 8 weeks of age (J:115744)
• spleen is about 4-fold smaller than in wild-type at 8 weeks of age (J:115744)
• reduction in splenic cellularity by 21 and 28 days of age (J:115744)
• spleens at 3-4 weeks of age show a reduction in lymphocyte numbers, with T cell numbers reduced about 5-fold and B cell numbers reduced more than 10-fold (J:115744)
• reduction in splenic cellularity by 21 and 28 days of age (J:115744)
• spleens at 3-4 weeks of age show a reduction in lymphocyte numbers, with T cell numbers reduced about 5-fold and B cell numbers reduced more than 10-fold (J:115744)

digestive/alimentary system
• loss of acinar cells, due to progressive apoptosis, in the exocrine pancreas between 1 and 3 weeks of age such that by 3 weeks of age, mutants have only about 1/2 the number of pancreatic acinar cells, despite normal appearance of ductal and endocrine islet cells (J:115744)
• loss of acinar cells, due to progressive apoptosis, in the exocrine pancreas between 1 and 3 weeks of age such that by 3 weeks of age, mutants have only about 1/2 the number of pancreatic acinar cells, despite normal appearance of ductal and endocrine islet cells (J:115744)
• acinar cells exhibit a reduction in size and number of dense zymogen granules in the cytoplasm and a lack of dense material within the ductal network (J:115744)
• acinar cells exhibit a reduction in size and number of dense zymogen granules in the cytoplasm and a lack of dense material within the ductal network (J:115744)
• pancreatic insufficiency is characterized by loss of pancreatic acinar cells resulting in mice that are unable to absorb nutrients from the diet, stunting growth and giving rise to immunological anomalies (J:115744)
• pancreatic enzyme diet supplementation or BAC transgene rescue restores size, weight, viability and immune cell numbers (J:115744)
• pancreatic insufficiency is characterized by loss of pancreatic acinar cells resulting in mice that are unable to absorb nutrients from the diet, stunting growth and giving rise to immunological anomalies (J:115744)
• pancreatic enzyme diet supplementation or BAC transgene rescue restores size, weight, viability and immune cell numbers (J:115744)


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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory