Mouse Genome Informatics
hm
    Map3k14aly/Map3k14aly
involves: C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• the frequency and number of dendritic cells in the spleen are decreased compared to in wild-type mice
• spleens exhibit decreased CD4+ CD25+ regulatory T cells compared with wild-type spleens
• 2 weeks post-infection with N. brasiliensis, mast cell numbers are decreased compared to in similarly treated wild-type mice
• between 18 and 84 days post-infection with H. polygyrus, mast cell counts in the jejunum are lower than in similarly treated wild-type mice
• thymic Valpha14i NKT cells are NK1.1+CD44+ indicating a block late in Valpha14i NKT cell development
• Valpha14i NKT cells are reduced in the thymus, spleen, liver, and bone marrow compared to in wild-type mice
• the spleen and thymus contain reduced percentage an total numbers of CD4+CD25+ regulatory T cells compared to in wild-type mice (J:87993)
• decreased numbers in the spleen (J:128211)
• mice exhibit an increase in the number of thymic cysts compared with wild-type mice
• cysts contain some lymphocytes and macrophages and have many projections unlike in wild-type mice
• the thymus medullas is smaller and contains fewer epithelial cells than in heterogyzotes
• T cell infiltrates in the salivary gland, lacrimal gland, and kidney exhibit antigen-driven clonal expansion
• N. brasiliensis- or H. polygyrus-infected mice fail to exhibit an increase in IgE levels unlike similarly treated wild-type mice
• in alpha-GalCer-treated mice
• in alpha-GalCer-treated mice
• dendritic cells exhibit impaired ability to induce expansion of CD4+ CD25+ regulatory T cells compared with wild-type cells
• some mononuclear cells infiltrate focally into the perivascular regions of all organs unlike in wild-type mice (J:38580)
• by 8 to 12 weeks, mice exhibit mild to moderate lymphoid infiltration in every tissue examined with follicle-like lymphoid aggregation in the lungs and less lymphoid aggregation in the gastrointestinal tract unlike in heterozygous mice (J:48224)
• mononuclear cells infiltrate around the lacrimal ducts unlike in wild-type mice
• after 10 weeks, mice exhibit lymphoid infiltrate around the pancreatic ducts unlike in heterozygous mice
• inflammation occurs in intrahepatic, large, and extrahepatic bile ducts
• mononuclear cells infiltrate around the interstitum in the kidney unlike in wild-type mice
• by 8 to 12 weeks, mice exhibit follicle-like lymphoid aggregation in the lungs unlike in heterozygous mice
• 18 days post-infection with Heligmosomoides polygyrus, egg per gram feces (EPG) is increased compared to in similarly treated wild-type mice
• however, EPG at 70 days post-infection with H. polygyrus and N. brasiliensis clearance are normal
• 2 weeks post-infection with Nippostrongylus brasiliensis, mast cell numbers are decreased compared to in similarly treated wild-type mice
• between 18 and 84 days post-infection with H. polygyrus, mast cell counts in the jejunim are lower than in similarly treated wild-type mice
• 18 days after H. polygyrus infection, intestinal goblet cells are decreased compared to in similarly treated wild-type mice
• N. brasiliensis- or H. polygyrus-infected mice fail to exhibit an increase in IgE levels unlike similarly treated wild-type mice

liver/biliary system
• inflammation occurs in intrahepatic, large, and extrahepatic bile ducts
• mice exhibit mild to moderate lymphoid infiltration around vessels and the portal areas in the hepatobiliary system unlike in heterozygous mice
• infiltrating lymphoid cells are predominantly CD4+
• 10% to 30% of portal tracts exhibit infiltration of lymphoid cells
• bile ducts exhibit pseudopyloric gland metaplasia
• however, no ductopenia nor fibrotic changes are observed
• biliary epithelial cells exhibit a cytoplasmic accumulation of acidophilic substance stained by the anti-cystatin C antibody
• following inflammation

endocrine/exocrine glands
• mononuclear cells infiltrate around the salivary ducts unlike in wild-type mice (J:38580)
• after 10 weeks, mice exhibit lymphoid infiltrate around the salivary ducts unlike in heterozygous mice (J:48224)
• bile ducts exhibit pseudopyloric gland metaplasia
• however, no ductopenia nor fibrotic changes are observed
• biliary epithelial cells exhibit a cytoplasmic accumulation of acidophilic substance stained by the anti-cystatin C antibody
• following inflammation
• mice exhibit an increase in end-bud development compared with heterozygous mice (J:117313)
• mononuclear cells infiltrate around the lacrimal ducts unlike in wild-type mice
• after 10 weeks, mice exhibit lymphoid infiltrate around the pancreatic ducts unlike in heterozygous mice

digestive/alimentary system
• number of proliferating IECs, and MHC class II expression on IECs are upregulated to a small extent in mutants compared to wild-type controls
• 18 days after H. polygyrus infection, intestinal goblet cells are decreased compared to in similarly treated wild-type mice
• mononuclear cells infiltrate around the salivary ducts unlike in wild-type mice (J:38580)
• after 10 weeks, mice exhibit lymphoid infiltrate around the salivary ducts unlike in heterozygous mice (J:48224)

adipose tissue
• mammary gland weight and thickness are decreased compared to in heterozygous mice
• mammary gland fat pad in virgin mice is smaller and thinner than in heterogyzous mice
• during pregnancy, mammary gland fat pad is smaller than in heterozygous mice

renal/urinary system
• mononuclear cells infiltrate around the interstitum in the kidney unlike in wild-type mice

vision/eye
• mononuclear cells infiltrate around the lacrimal ducts unlike in wild-type mice

hematopoietic system
• the frequency and number of dendritic cells in the spleen are decreased compared to in wild-type mice
• spleens exhibit decreased CD4+ CD25+ regulatory T cells compared with wild-type spleens
• 2 weeks post-infection with N. brasiliensis, mast cell numbers are decreased compared to in similarly treated wild-type mice
• between 18 and 84 days post-infection with H. polygyrus, mast cell counts in the jejunum are lower than in similarly treated wild-type mice
• thymic Valpha14i NKT cells are NK1.1+CD44+ indicating a block late in Valpha14i NKT cell development
• Valpha14i NKT cells are reduced in the thymus, spleen, liver, and bone marrow compared to in wild-type mice
• T cell infiltrates in the salivary gland, lacrimal gland, and kidney exhibit antigen-driven clonal expansion
• the spleen and thymus contain reduced percentage an total numbers of CD4+CD25+ regulatory T cells compared to in wild-type mice (J:87993)
• decreased numbers in the spleen (J:128211)
• mice exhibit an increase in the number of thymic cysts compared with wild-type mice
• cysts contain some lymphocytes and macrophages and have many projections unlike in wild-type mice
• the thymus medullas is smaller and contains fewer epithelial cells than in heterogyzotes
• N. brasiliensis- or H. polygyrus-infected mice fail to exhibit an increase in IgE levels unlike similarly treated wild-type mice

respiratory system
• by 8 to 12 weeks, mice exhibit follicle-like lymphoid aggregation in the lungs unlike in heterozygous mice

homeostasis/metabolism
• in alpha-GalCer-treated mice
• in alpha-GalCer-treated mice

integument
• mice exhibit an increase in end-bud development compared with heterozygous mice (J:117313)

Mouse Models of Human Disease
OMIM IDRef(s)
Biliary Cirrhosis, Primary, 1; PBC1 109720 J:48224
Sjogren Syndrome 270150 J:38580