Phenotypes Associated with This Genotype

Genotype
MGI:3767323

• Allelic Composition: Tcra^tm1Mom/Tcra^tm1Mom
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

colitis ( J:15221 )

• colitis occurs in mice as they age (4 months and over)

• disease resembles the human disease ulcerative colitis

arrested T cell differentiation ( J:3206 )

• T cells in the thymus do not pass the double positive stage

decreased CD4-positive, alpha-beta T cell number ( J:3206 )

• very few T cells are found in the thymus or periphery

decreased CD8-positive, alpha-beta T cell number ( J:3206 )

• very few CD8 T cells are found in the thymus or periphery

increased gamma-delta intraepithelial T cell number ( J:15221 )

• numbers are markedly increased

decreased IgG level ( J:119344 )

• mice do not produce IgG following infection, although M. pulmonis-specific IgM antibodies are detected

abnormal response to infection ( J:119344 )

• airway vascular and airway lymphatic vessel remodeling are impaired or absent compared to wild-type mice after M. pulmonis infection

respiratory system

abnormal respiratory system morphology ( J:119344 )

• M. pulmonis infected mice show a diminished or intermediate airway remodeling phenotype when compared to wild-type or Igh-6 deficient mice

hematopoietic system

arrested T cell differentiation ( J:3206 )

• T cells in the thymus do not pass the double positive stage

decreased CD4-positive, alpha-beta T cell number ( J:3206 )

• very few T cells are found in the thymus or periphery

decreased CD8-positive, alpha-beta T cell number ( J:3206 )

• very few CD8 T cells are found in the thymus or periphery

increased gamma-delta intraepithelial T cell number ( J:15221 )

• numbers are markedly increased

decreased IgG level ( J:119344 )

• mice do not produce IgG following infection, although M. pulmonis-specific IgM antibodies are detected

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:15221 )

• pronounced depletion of goblet cells resulting from inflammation

crypts of Lieberkuhn abscesses ( J:15221 )

• caused by neutrophil infiltration

intestinal ulcer ( J:15221 )

• occurs in rare cases

rectal prolapse ( J:15221 )

• occurs in mice over 4 months of age

chronic diarrhea ( J:15221 )

• is observed in older mice

colitis ( J:15221 )

• colitis occurs in mice as they age (4 months and over)

• disease resembles the human disease ulcerative colitis

endocrine/exocrine glands

crypts of Lieberkuhn abscesses ( J:15221 )

• caused by neutrophil infiltration

mortality/aging

premature death ( J:15221 )

• mortality rates increase after six months of age

• few mice survive longer than one year

cellular

abnormal intestinal goblet cell morphology ( J:15221 )

• pronounced depletion of goblet cells resulting from inflammation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
inflammatory bowel disease		DOID:0050589	OMIM:PS266600	J:15221