Phenotypes Associated with This Genotype

Genotype
MGI:3767181

• Allelic Composition: Atoh1^tm2Hzo/Atoh1^tm3Hzo; Tg(Fabp1-cre)1Jig/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:128312 )

N • unlike mice with complete recombination of the floxed allele in the entire intestinal epithelium, mice with a mosaic pattern of recombination show no increase in mortality up to at least 1 year of age

digestive/alimentary system

abnormal small intestine crypts of Lieberkuhn morphology ( J:128312 )

• the small intestine contains patches of abnormal crypts with a recombined allele mixed with areas of normal crypts with an unrecombined allele

• crypts with the recombined allele completely lack goblet, Paneth, and enteroendocrine cells instead containing only absorptive enterocytes

• a significant increase in BrdU+ cells and mitotic figures is seen in crypts with a recombined allele

• crypts with a recombined allele are smaller than neighboring crypts in which recombination did not occur

impaired intestine regeneration ( J:128312 )

• the adaptive response following resection of the middle 50% of the small bowel is blunted with a smaller increase in crypt depth compared to control mice

endocrine/exocrine glands

abnormal small intestine crypts of Lieberkuhn morphology ( J:128312 )

• the small intestine contains patches of abnormal crypts with a recombined allele mixed with areas of normal crypts with an unrecombined allele

• crypts with the recombined allele completely lack goblet, Paneth, and enteroendocrine cells instead containing only absorptive enterocytes

• a significant increase in BrdU+ cells and mitotic figures is seen in crypts with a recombined allele

• crypts with a recombined allele are smaller than neighboring crypts in which recombination did not occur