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Phenotypes Associated with This Genotype
Genotype
MGI:3767177
Allelic
Composition
Ctsktm1Mbs/Ctsktm1Mbs
Genetic
Background
B6.129-Ctsktm1Mbs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsktm1Mbs mutation (0 available); any Ctsk mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• increased thickness
• femoral mid-diaphyses show high levels of bone remodeling with 5 - 7 active remodeling sites detected in contrast to wild-type bones where no remodeling is detected
• about a 2- to 3-fold increase in osteoclast number and 45 - 65% increase in resportion surface
• reduced cavity size in long bones
• cortical bone contains both areas with normal lamellar structure as well as regions of disorganized bone matrix
• significant increase in long bone cortical bone area
• increase in endocortical resorption surface
• about a 2-fold increase in trabecular number throughout the metaphyseal region
• about a 2- and 4-fold increase in trabecular bone mass in males and females, respectively, compared to wild-type mice
• mild osteopetrosis in cancellous bone regions
• femoral mid-diaphyses show high levels of bone remodeling with 5 - 7 active remodeling sites detected in contrast to wild-type bones where no remodeling is detected
• significant increase in mineral apposition rates and surface- and tissue area-based bone formation rates in cancellous bone
• however, there is no change in osteoblast number or in osteoid and mineralizing surfaces
• cancellous bone displays highly abnormal resorption foci with shallow Howship's lacunae filled with a layer of unresorbed demineralized bone
• resorption lacunae are also overlain with flattened cells resembling bone lining cells rather than osteoclasts
• diaphyseal strength (maximum load) and stiffness are increased by 14% and 44%, respectively, compared to wild-type controls
• femurs show a 50 - 70% decrease in post yield deflection and a 30 - 40% decrease in work-to-failure compared to wild-type bones

hematopoietic system
• about a 2- to 3-fold increase in osteoclast number and 45 - 65% increase in resportion surface
• resorption lacunae are also overlain with flattened cells resembling bone lining cells rather than osteoclasts
• cancellous bone displays highly abnormal resorption foci with shallow Howship's lacunae filled with a layer of unresorbed demineralized bone

immune system
• about a 2- to 3-fold increase in osteoclast number and 45 - 65% increase in resportion surface
• cancellous bone displays highly abnormal resorption foci with shallow Howship's lacunae filled with a layer of unresorbed demineralized bone
• resorption lacunae are also overlain with flattened cells resembling bone lining cells rather than osteoclasts

cellular
• significant increase in mineral apposition rates and surface- and tissue area-based bone formation rates in cancellous bone
• however, there is no change in osteoblast number or in osteoid and mineralizing surfaces


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory