Mouse Genome Informatics
hm
    Timo/Timo
either: B6.Cg-Timo or (involves: C57BL/6J * CBA/CaJ)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• by 67 weeks of age the mortality rate is about 15% in both males and females compared to 0% in heterozygous and non-transgenic mice

growth/size/body
• increase in both total amount and percent of body fat
• increase in both total amount and percent of body fat
• significant increase in body weight by 6 to 7 weeks of age
• females and males are 119 and 37% heavier than age-matched non-transgenic controls by 69 weeks of age
• at 24 weeks of age, mean lengths of female and male mice are increased by about 11 and 7%, respectively

adipose tissue
• increase in both total amount and percent of body fat
• increase in both total amount and percent of body fat

homeostasis/metabolism
• increased about 10-fold compared to non-transgenic controls
• increased by 95% compared to non-transgenic controls
• elevation in the LDL but not HDL, serum cholesterol levels
• develops by 9 weeks of age
• in mice older than 8 weeks
• detected at 6 weeks of age prior to onset of obesity and in mice over 8 weeks of age

behavior/neurological
• mice consume 57% more food than non-transgenic controls
• however, no change in energy expenditure is detected
• in a resident-intruder assay latencies to first biting attacks are shorter and duration of biting attacks are longer compared to non-transgenic controls

liver/biliary system

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:127183
Obesity 601665 J:127183