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Phenotypes Associated with This Genotype
Genotype
MGI:3766122
Allelic
Composition
Timo/Timo
Genetic
Background
either: B6.Cg-Timo or (involves: C57BL/6J * CBA/CaJ)
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• by 67 weeks of age the mortality rate is about 15% in both males and females compared to 0% in heterozygous and non-transgenic mice (J:127183)
• by 67 weeks of age the mortality rate is about 15% in both males and females compared to 0% in heterozygous and non-transgenic mice (J:127183)

growth/size/body
• increase in both total amount and percent of body fat (J:127183)
• increase in both total amount and percent of body fat (J:127183)
• increase in both total amount and percent of body fat (J:127183)
• increase in both total amount and percent of body fat (J:127183)
• significant increase in body weight by 6 to 7 weeks of age (J:127183)
• females and males are 119 and 37% heavier than age-matched non-transgenic controls by 69 weeks of age (J:127183)
• significant increase in body weight by 6 to 7 weeks of age (J:127183)
• females and males are 119 and 37% heavier than age-matched non-transgenic controls by 69 weeks of age (J:127183)
• at 24 weeks of age, mean lengths of female and male mice are increased by about 11 and 7%, respectively (J:127183)
• at 24 weeks of age, mean lengths of female and male mice are increased by about 11 and 7%, respectively (J:127183)

adipose tissue
• increase in both total amount and percent of body fat (J:127183)
• increase in both total amount and percent of body fat (J:127183)
• increase in both total amount and percent of body fat (J:127183)
• increase in both total amount and percent of body fat (J:127183)

homeostasis/metabolism
• increased about 10-fold compared to non-transgenic controls (J:127183)
• increased about 10-fold compared to non-transgenic controls (J:127183)
• increased by 95% compared to non-transgenic controls (J:127183)
• increased by 95% compared to non-transgenic controls (J:127183)
• elevation in the LDL but not HDL, serum cholesterol levels (J:127183)
• elevation in the LDL but not HDL, serum cholesterol levels (J:127183)
• develops by 9 weeks of age (J:127183)
• develops by 9 weeks of age (J:127183)
• in mice older than 8 weeks (J:127183)
• in mice older than 8 weeks (J:127183)
• detected at 6 weeks of age prior to onset of obesity and in mice over 8 weeks of age (J:127183)
• detected at 6 weeks of age prior to onset of obesity and in mice over 8 weeks of age (J:127183)

behavior/neurological
• mice consume 57% more food than non-transgenic controls (J:127183)
• however, no change in energy expenditure is detected (J:127183)
• mice consume 57% more food than non-transgenic controls (J:127183)
• however, no change in energy expenditure is detected (J:127183)
• in a resident-intruder assay latencies to first biting attacks are shorter and duration of biting attacks are longer compared to non-transgenic controls (J:127183)
• in a resident-intruder assay latencies to first biting attacks are shorter and duration of biting attacks are longer compared to non-transgenic controls (J:127183)

liver/biliary system


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory