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Phenotypes Associated with This Genotype
Genotype
MGI:3766068
Allelic
Composition
Smad4E6sad/Smad4+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad4E6sad mutation (0 available); any Smad4 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• tumors ranging in size from 1 to 5 mm are found immediately distal to the pyloric/duodenal transition in mice over 16 months of age
• tumors are heterogeneous with 30% being serrated adenomas
• two out of fifteen mice have small hyperplastic lesions present in the gastric mucosa

digestive/alimentary system
• some of the polyps found distal of the pyloric/duodenal transition have gastric surface epithelial cells
• tumors ranging in size from 1 to 5 mm are found immediately distal to the pyloric/duodenal transition in mice over 16 months of age
• tumors are heterogeneous with 30% being serrated adenomas
• two out of fifteen mice have small hyperplastic lesions present in the gastric mucosa


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory