Phenotypes Associated with This Genotype

Genotype
MGI:3766068

• Allelic Composition: Smad4^E6sad/Smad4⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased intestinal adenoma incidence ( J:81488 )

• tumors ranging in size from 1 to 5 mm are found immediately distal to the pyloric/duodenal transition in mice over 16 months of age

• tumors are heterogeneous with 30% being serrated adenomas

increased stomach tumor incidence ( J:81488 )

• two out of fifteen mice have small hyperplastic lesions present in the gastric mucosa

digestive/alimentary system

stomach epithelial hyperplasia ( J:81488 )

• some of the polyps found distal of the pyloric/duodenal transition have gastric surface epithelial cells

increased intestinal adenoma incidence ( J:81488 )

• tumors ranging in size from 1 to 5 mm are found immediately distal to the pyloric/duodenal transition in mice over 16 months of age

• tumors are heterogeneous with 30% being serrated adenomas

increased stomach tumor incidence ( J:81488 )

• two out of fifteen mice have small hyperplastic lesions present in the gastric mucosa