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Phenotypes Associated with This Genotype
Genotype
MGI:3765154
Allelic
Composition
Kcnn2fri/Kcnn2fri
Genetic
Background
involves: C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnn2fri mutation (0 available); any Kcnn2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• rapid tremors reminiscent of the quaking phenotype (J:13711)
• tremors are Parkinson-like (J:70213)
• 10,20,and 40 mg/kg L-Dopa improved motor performance
• 10 mg/kg Seligiline treatments improved motor performance
• 20 mg/kg Ropinirole treatment increased motor performance
• unable to walk on a rotarod bar
• unable to normally traverse an inclined plane
• while suspended unable to coordinate hindpaws to grasp thread held by front paws
• number rearings significantly increased following adminstration of between 10 and 60 mg/kg L-Dopa
• width of foot placement is greater than for control
• intrastep distance is also shorter

nervous system
• histological evidence of degeneration
• histological evidence of degeneration


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory