Phenotypes Associated with This Genotype

Genotype
MGI:3764847

• Allelic Composition: Ccm2^{Gt(RRG051)Byg}/Ccm2^{Gt(RRG051)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:146527 )

• mice die between E9-E10 from failed angiogenesis

prenatal lethality, complete penetrance ( J:105314 )

• no live-born homozygotes are observed; time of lethality not specified

cardiovascular system

abnormal cardiovascular system morphology ( J:146527 )

dilated dorsal aorta ( J:146527 )

• the caudal portion of the dorsal aorta becomes enlarged in 8.5 embryos

abnormal pharyngeal arch artery morphology ( J:146527 )

• the branchial arch arteries, the first essential angiogenic vessels, fail to form a stable lumen in E8.5 embryos

abnormal first pharyngeal arch artery morphology ( J:146527 )

• the first branchial arch artery of E8.5 embryos fails to form a proper lumen

abnormal second pharyngeal arch artery morphology ( J:146527 )

• the second branchial arch artery of E8.5 embryos fails to form a proper lumen

abnormal third pharyngeal arch artery morphology ( J:146527 )

• the third branchial arch artery of E8.5 embryos fail to form a proper lumen

aorta stenosis ( J:146527 )

• adjacent portions of the aorta are narrow and irregular

decreased angiogenesis ( J:146527 )

• the branchial arch arteries, the first essential angiogenic vessels, fail to form a stable lumen in E8.5 embryos

• the heart is not functionally connected with the vasculature, and circulation fails to initiate

abnormal vitelline vasculature morphology ( J:146527 )

• E9.0 embryos fail to organize the yolk sac vasculature

poor circulation ( J:146527 )

• circulation is not established in E8.5 embryos

craniofacial

abnormal pharyngeal arch morphology ( J:146527 )

abnormal pharyngeal arch artery morphology ( J:146527 )

• the branchial arch arteries, the first essential angiogenic vessels, fail to form a stable lumen in E8.5 embryos

abnormal first pharyngeal arch artery morphology ( J:146527 )

• the first branchial arch artery of E8.5 embryos fails to form a proper lumen

abnormal second pharyngeal arch artery morphology ( J:146527 )

• the second branchial arch artery of E8.5 embryos fails to form a proper lumen

abnormal third pharyngeal arch artery morphology ( J:146527 )

• the third branchial arch artery of E8.5 embryos fail to form a proper lumen

embryo

abnormal vitelline vasculature morphology ( J:146527 )

• E9.0 embryos fail to organize the yolk sac vasculature

abnormal pharyngeal arch morphology ( J:146527 )

abnormal pharyngeal arch artery morphology ( J:146527 )

• the branchial arch arteries, the first essential angiogenic vessels, fail to form a stable lumen in E8.5 embryos

abnormal first pharyngeal arch artery morphology ( J:146527 )

• the first branchial arch artery of E8.5 embryos fails to form a proper lumen

abnormal second pharyngeal arch artery morphology ( J:146527 )

• the second branchial arch artery of E8.5 embryos fails to form a proper lumen

abnormal third pharyngeal arch artery morphology ( J:146527 )

• the third branchial arch artery of E8.5 embryos fail to form a proper lumen

abnormal vitelline vascular remodeling ( J:146527 )

• yolk sac vascular remodeling is abnormal in E8.5 embryos