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Phenotypes Associated with This Genotype
Genotype
MGI:3764007
Allelic
Composition
Gt(ROSA)26Sortm2(Mirn150)Rsky/Gt(ROSA)26Sortm2(Mirn150)Rsky
Genetic
Background
involves: C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Mirn150)Rsky mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in culture, increased cell death in bone marrow pro-B cells is observed compared to controls (increase in sub-G0 population is seen)
• B cell number particularly B-1 B cells are lower than controls and 3-12 weeks and remain lower at 18-41 weeks of age
• B-2 cell number is lower than controls at 3-12 weeks of age
• mature T cells in spleen are reduced in numbers at young age and become comparable to controls at 18-41 weeks of age
• mature T cells in spleen are reduced in numbers at young age and become comparable to controls at 18-41 weeks of age

hematopoietic system
• in culture, increased cell death in bone marrow pro-B cells is observed compared to controls (increase in sub-G0 population is seen)
• B cell number particularly B-1 B cells are lower than controls and 3-12 weeks and remain lower at 18-41 weeks of age
• B-2 cell number is lower than controls at 3-12 weeks of age
• mature T cells in spleen are reduced in numbers at young age and become comparable to controls at 18-41 weeks of age
• mature T cells in spleen are reduced in numbers at young age and become comparable to controls at 18-41 weeks of age

cellular
• in culture, increased cell death in bone marrow pro-B cells is observed compared to controls (increase in sub-G0 population is seen)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory