Phenotypes Associated with This Genotype

Genotype
MGI:3763712

• Allelic Composition: Fgf2^tm1Doe/Fgf2^tm1Doe
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal response to cardiac infarction ( J:126804 )

• left ventricle chamber is increased 10-fold 4 weeks after infarct induction compared to wild-type mice in which dilation is 6-fold

• expansion index at 4 weeks post-infarct induction is twice as much as in wild-type mice

• following infarct induction mice exhibit less cardiomyocyte hypertrophy (4% increase in cross-section area compared to 19% increase in cross-section area in wild-type mice)

• fibroblast proliferation at 4 days and 1 week post-infarct induction is decreased 33% and 59%, respectively, compared to in wild-type mice

• interstitial fibrosis fails to increase as in wild-type mice after infarct induction

• the decline in vascular density declines more dramatically following myocardial infarct induction compared to in wild-type mice (74% versus 25% at week 1 week, 91% versus 75% at 4 weeks)

• following myocardial infarct induction, the average area per vessel is increased 10-fold compared to in wild-type mice (122.9+/-23.4 um² compared to 38.7+/-7.9 um² in wild-type mice and these large sinusoidal vessels often lack smooth muscle/pericyte investment

• however, vessel area is unchanged even after myocardial infarct induction

• following infarct induction, left ventricular function is decreased 20% compared to 11% in wild-type mice

increased myocardial infarct size ( J:126804 )

• cardiac infarcts fail to undergo scar contraction after 4 weeks as in wild-type mice

• however, there is no difference in infarct composition or initial size

homeostasis/metabolism

abnormal response to cardiac infarction ( J:126804 )

• left ventricle chamber is increased 10-fold 4 weeks after infarct induction compared to wild-type mice in which dilation is 6-fold

• expansion index at 4 weeks post-infarct induction is twice as much as in wild-type mice

• following infarct induction mice exhibit less cardiomyocyte hypertrophy (4% increase in cross-section area compared to 19% increase in cross-section area in wild-type mice)

• fibroblast proliferation at 4 days and 1 week post-infarct induction is decreased 33% and 59%, respectively, compared to in wild-type mice

• interstitial fibrosis fails to increase as in wild-type mice after infarct induction

• the decline in vascular density declines more dramatically following myocardial infarct induction compared to in wild-type mice (74% versus 25% at week 1 week, 91% versus 75% at 4 weeks)

• following myocardial infarct induction, the average area per vessel is increased 10-fold compared to in wild-type mice (122.9+/-23.4 um² compared to 38.7+/-7.9 um² in wild-type mice and these large sinusoidal vessels often lack smooth muscle/pericyte investment

• however, vessel area is unchanged even after myocardial infarct induction

• following infarct induction, left ventricular function is decreased 20% compared to 11% in wild-type mice

increased myocardial infarct size ( J:126804 )

• cardiac infarcts fail to undergo scar contraction after 4 weeks as in wild-type mice

• however, there is no difference in infarct composition or initial size