About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3763530
Allelic
Composition
DgkdGt(RRT600)Byg/DgkdGt(RRT600)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
DgkdGt(RRT600)Byg mutation (1 available); any Dgkd mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 3 of 6 homozygotes showed discrete seizures in association with rhythmic electromyography activities, no seizures were seen in wild-type controls
• one of these mice showed bilateral ictal discharge while the other 2 showed ictal EEG activity confined to a single hemisphere

neoplasm
• 2 of 21 homozygotes developed tumors by 15 months of age compared to no tumors in wild-type littermates
• one of these mice had squamous cell carcinoma of the tongue at 11 months of age and the other developed a hepatoma by 15 months of age

behavior/neurological
• 3 of 6 homozygotes showed discrete seizures in association with rhythmic electromyography activities, no seizures were seen in wild-type controls
• one of these mice showed bilateral ictal discharge while the other 2 showed ictal EEG activity confined to a single hemisphere

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Lennox-Gastaut syndrome DOID:0050561 OMIM:606369
J:126380


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/10/2022
MGI 6.19
The Jackson Laboratory