immune system
• homozygous mice exhibit reduced numbers of germinal center B cells in gut-associated lymphoid tissue (GALT), including Peyer's patches and mesenteric lymph nodes
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• B cells exhibit deficient cytokine production
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• T cells show a Th2 cytokine bias (increased Il4-producing and decreased IFNgamma-producing cell numbers) with a higher fraction of interleukin-10 producing cells
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• mice show impaired T cell-dependent antibody responses
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• B cells exhibit deficient TNFalpha and lymphotoxin A (LT-a) cytokine production
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hematopoietic system
• homozygous mice exhibit reduced numbers of germinal center B cells in gut-associated lymphoid tissue (GALT), including Peyer's patches and mesenteric lymph nodes
|
• B cells exhibit deficient cytokine production
|
• T cells show a Th2 cytokine bias (increased Il4-producing and decreased IFNgamma-producing cell numbers) with a higher fraction of interleukin-10 producing cells
|