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Phenotypes Associated with This Genotype
Genotype
MGI:3763429
Allelic
Composition
Mir155tm1.1Rsky/Mir155tm1.1Rsky
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir155tm1.1Rsky mutation (1 available); any Mir155 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• homozygous mice exhibit reduced numbers of germinal center B cells in gut-associated lymphoid tissue (GALT), including Peyer's patches and mesenteric lymph nodes
• B cells exhibit deficient cytokine production
• T cells show a Th2 cytokine bias (increased Il4-producing and decreased IFNgamma-producing cell numbers) with a higher fraction of interleukin-10 producing cells
• mice show impaired T cell-dependent antibody responses
• B cells exhibit deficient TNFalpha and lymphotoxin A (LT-a) cytokine production

hematopoietic system
• homozygous mice exhibit reduced numbers of germinal center B cells in gut-associated lymphoid tissue (GALT), including Peyer's patches and mesenteric lymph nodes
• B cells exhibit deficient cytokine production
• T cells show a Th2 cytokine bias (increased Il4-producing and decreased IFNgamma-producing cell numbers) with a higher fraction of interleukin-10 producing cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory