About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3763424
Allelic
Composition
Flt3tm1Dgg/Flt3tm1Dgg
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt3tm1Dgg mutation (1 available); any Flt3 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• bone marrow cells exhibit a two-fold increase in the Lin-Sca1+cKit+ (LSK) compartment compared to in wild-type and heterozygous mice
• monocytes are present in the bone marrow and liver in a background of increased number of maturing myeloid cells is increased compared to in wild-type mice
• the relative percentage of immunophenotypic granulocyte-monocyte progenitors is expanded while the percent of megakaryocyte-erythroid progenitors is decreased
• however, the total number of myeloid progenitor cells is the same as in wild-type mice
• the proportion of LSK cells in S/G2/M phase is increased while the proportion in G0/G1 is increased compared to in wild-type mice
• fewer LSK cells undergo apoptosis compared to in wild-type and heterozygous mice
• when cultured on methylcellulose, bone marrow cells produce more colonies than wild-type cells with a greater number of monocytes and fewer erythroid burst forming units and granulocyte-erythroid burst forming units compared to wild-type and heterozygous mice
• however, re-plated colonies do not exhibit increased self-renewal properties
• B cell maturation is blocked at the pre-B stage
• the rise in monocytes in the bone marrow and spleen is accompanied by a decrease in the percentage of T and B lymphoid cells
• the number of mature B cells in the bone marrow and spleen is decreased compared to in wild-type mice
• the rise in monocytes in the bone marrow and spleen is accompanied by a decrease in the percentage of T and B lymphoid cells
• mice exhibit leukocytosis and monocytosis with a reversal in the neutrophil to lymphocyte ratio compared to in wild-type mice
• granulocyte populations are increased in peripheral blood compared to in wild-type mice
• monocyte populations are increased in peripheral blood
• monocytes are present in the bone marrow and liver in a background of increased number of maturing myeloid cells is increased compared to in wild-type mice
• expanded red pulp is comprised of mainly mature myeloid and ad-mixed erythroid elements
• mice develop a variable and progressive splenomegaly that is more severe than in heterozygous mice
• expanded white pulp is comprised of cells resembling maturing monocytes

immune system
• B cell maturation is blocked at the pre-B stage
• the rise in monocytes in the bone marrow and spleen is accompanied by a decrease in the percentage of T and B lymphoid cells
• the number of mature B cells in the bone marrow and spleen is decreased compared to in wild-type mice
• the rise in monocytes in the bone marrow and spleen is accompanied by a decrease in the percentage of T and B lymphoid cells
• mice exhibit leukocytosis and monocytosis with a reversal in the neutrophil to lymphocyte ratio compared to in wild-type mice
• granulocyte populations are increased in peripheral blood compared to in wild-type mice
• monocyte populations are increased in peripheral blood
• monocytes are present in the bone marrow and liver in a background of increased number of maturing myeloid cells is increased compared to in wild-type mice
• expanded red pulp is comprised of mainly mature myeloid and ad-mixed erythroid elements
• mice develop a variable and progressive splenomegaly that is more severe than in heterozygous mice
• expanded white pulp is comprised of cells resembling maturing monocytes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
juvenile myelomonocytic leukemia DOID:0050458 OMIM:607785
J:126003


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/18/2020
MGI 6.14
The Jackson Laboratory