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Phenotypes Associated with This Genotype
Genotype
MGI:3763233
Allelic
Composition		 Pdcd1lg2tm1.1Lex/Pdcd1lg2tm1.1Lex
Genetic
Background		 involves: 129S5/SvEvBrd
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Mouse lines carrying:
Pdcd1lg2tm1.1Lex mutation (0 available); any Pdcd1lg2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:126829 )
• a small reduction in the percentage of CD8+ T cells in lymph nodes and spleens
• no changes were observed for body weight, organ weight, hematology, clinical chemistry, and macroscopic or microscopic findings as compared to wild-type mice
• mice live over 1 year of age, consistent with the lack of obvious pathology

immune system
decreased CD8-positive, alpha-beta T cell number ( J:126829 )
• a small reduction in the percentage of CD8+ T cells in lymph nodes and spleens
• no changes were observed for body weight, organ weight, hematology, clinical chemistry, and macroscopic or microscopic findings as compared to wild-type mice
• mice live over 1 year of age, consistent with the lack of obvious pathology

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory