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Phenotypes Associated with This Genotype
Genotype
MGI:3762808
Allelic
Composition		 Prnptm4(PRNP)Tkit/Prnptm4(PRNP)Tkit
Tg(Prnp-PRNP)32Tkit/?
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm4(PRNP)Tkit mutation (0 available); any Prnp mutation (150 available)
Tg(Prnp-PRNP)32Tkit mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to prion infection ( J:105882 )
• mice are highly susceptible to bovine spongiform encephalopathy and variant Creutzfeldt-Jakob prion infection
• however, mice are not susceptible to sporadic or dura graft-associated prion infection

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory