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Phenotypes Associated with This Genotype
Genotype
MGI:3762763
Allelic
Composition
Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic
Background
involves: 129S1/SvImJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kiss1rtm1Rla mutation (0 available); any Kiss1r mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only two-third of expected homozygote progeny are produced from heterozygote parents

reproductive system
• 13.1 + 1mm versus 17 + 2mm in wild-type mice
• this divergent first occurs in days 23-25 post birth this divergent first occurs in days 23-25 post birth
• ovary weight is 1/6th of normal
• either absent or in greatly reduced numbers
• difficult to detect
• difficult to detect
• reduced number of cells due to small small size of testis
• mean is 24.2 grams compared to 141 grams for wild-type mice
• occurs on average 10 days later than in wild-type mice
• absence of estrous cycling in 9-11 week old female mice
• unable to produce offspring with wild-type partners
• unable to produce offspring with wild-type partners

growth/size/body
• average weight of male mice is 3 grams less than wild-type littermates

endocrine/exocrine glands
• difficult to detect
• difficult to detect
• ovary weight is 1/6th of normal
• reduced number of cells due to small small size of testis
• mean is 24.2 grams compared to 141 grams for wild-type mice

homeostasis/metabolism
• eight fold less in male mice
• more than 10 fold less in male mice
• 2 fold less in female mice
• four fold less in male mice

digestive/alimentary system
• 13.1 + 1mm versus 17 + 2mm in wild-type mice
• this divergent first occurs in days 23-25 post birth this divergent first occurs in days 23-25 post birth

renal/urinary system
• difficult to detect

integument
• difficult to detect


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory