About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3762762
Allelic
Composition
Kiss1tm1Rla/Kiss1tm1Rla
Genetic
Background
involves: 129S1/SvImJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kiss1tm1Rla mutation (0 available); any Kiss1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• 13.1 + 1mm versus 17 + 2mm in wild-type mice
• this divergence first occurs in days 23-25 post birth
• bimodal distribution with half similar to wild-type, and half having an ovary weight 1/6th of normal
• occurs in female mice that also have persistent vaginal cornification
• half of the mice have persistent vaginal cornification upon vaginal opening
• either absent or in greatly reduced numbers
• difficult to detect
• difficult to detect
• reduced number of cells due to small small size of testis
• mean weight of 39.0 grams compared to 141.0 grams for wild-type mice
• occurs on average 10 days later than in wild-type mice
• absence of estrous cycling in 9-11 week old female mice
• unable to produce offspring with wild-type partners
• unable to produce offspring with wild-type partners

endocrine/exocrine glands
• difficult to detect
• difficult to detect
• bimodal distribution with half similar to wild-type, and half having an ovary weight 1/6th of normal
• occurs in female mice that also have persistent vaginal cornification
• reduced number of cells due to small small size of testis
• mean weight of 39.0 grams compared to 141.0 grams for wild-type mice

homeostasis/metabolism

digestive/alimentary system
• 13.1 + 1mm versus 17 + 2mm in wild-type mice
• this divergence first occurs in days 23-25 post birth

renal/urinary system
• difficult to detect

integument
• difficult to detect


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/12/2016
MGI 6.04
The Jackson Laboratory