Mouse Genome Informatics
hm
    Kiss1tm1Rla/Kiss1tm1Rla
involves: 129S1/SvImJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
reproductive system
• 13.1 + 1mm versus 17 + 2mm in wild-type mice
• this divergence first occurs in days 23-25 post birth
• bimodal distribution with half similar to wild-type, and half having an ovary weight 1/6th of normal (J:126704)
• occurs in female mice that also have persistent vaginal cornification (J:126704)
• half of the mice have persistent vaginal cornification upon vaginal opening (J:126704)
• either absent or in greatly reduced numbers (J:126704)
• difficult to detect (J:126704)
• difficult to detect (J:126704)
• reduced number of cells due to small small size of testis (J:126704)
• mean weight of 39.0 grams compared to 141.0 grams for wild-type mice (J:126704)
• occurs on average 10 days later than in wild-type mice
• absence of estrous cycling in 9-11 week old female mice (J:126704)
• unable to produce offspring with wild-type partners (J:126704)
• unable to produce offspring with wild-type partners (J:126704)

endocrine/exocrine glands
• difficult to detect (J:126704)
• bimodal distribution with half similar to wild-type, and half having an ovary weight 1/6th of normal (J:126704)
• occurs in female mice that also have persistent vaginal cornification (J:126704)
• difficult to detect (J:126704)
• reduced number of cells due to small small size of testis (J:126704)
• mean weight of 39.0 grams compared to 141.0 grams for wild-type mice (J:126704)

homeostasis/metabolism

digestive/alimentary system
• 13.1 + 1mm versus 17 + 2mm in wild-type mice
• this divergence first occurs in days 23-25 post birth

renal/urinary system
• difficult to detect (J:126704)

integument
• difficult to detect (J:126704)

Mouse Models of Human Disease
OMIM IDRef(s)
Hypogonadotropic Hypogonadism 13 with or without Anosmia; HH13 614842 J:126704