Mouse Genome Informatics
cn
    Brca1tm1Brn/Brca1tm1Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0

involves: 129P2/OlaHsd * BALB/cJ * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• mice develop mammary gland with a latency of 213 days
• 80% of mice develop tumors compared to 63% of Trp53tm1Jjon/Trp53tm1Jjon Tg(KRT14-cre)8Jjon mice
• mice develop mammary types of carcinoma (91%), biphasic carcinoma that is poorly defined (3%) and biphasic carcinoma that is well defined (6%)

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:126551