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Phenotypes Associated with This Genotype
Genotype
MGI:3762188
Allelic
Composition
Brca1tm1Brn/Brca1tm1Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Brn mutation (2 available); any Brca1 mutation (75 available)
Tg(KRT14-cre)8Brn mutation (4 available)
Trp53tm1Brn mutation (6 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mice develop mammary gland with a latency of 213 days
• 80% of mice develop tumors compared to 63% of Trp53tm1Jjon/Trp53tm1Jjon Tg(KRT14-cre)8Jjon mice
• mice develop mammary types of carcinoma (91%), biphasic carcinoma that is poorly defined (3%) and biphasic carcinoma that is well defined (6%)

integument
• mice develop mammary gland with a latency of 213 days
• 80% of mice develop tumors compared to 63% of Trp53tm1Jjon/Trp53tm1Jjon Tg(KRT14-cre)8Jjon mice
• mice develop mammary types of carcinoma (91%), biphasic carcinoma that is poorly defined (3%) and biphasic carcinoma that is well defined (6%)

neoplasm
• mice develop mammary gland with a latency of 213 days
• 80% of mice develop tumors compared to 63% of Trp53tm1Jjon/Trp53tm1Jjon Tg(KRT14-cre)8Jjon mice
• mice develop mammary types of carcinoma (91%), biphasic carcinoma that is poorly defined (3%) and biphasic carcinoma that is well defined (6%)

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:126551


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory