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Phenotypes Associated with This Genotype
Genotype
MGI:3761628
Allelic
Composition
Serpinb1atm1.1Cben/Serpinb1atm1.1Cben
Genetic
Background
129S6/SvEvTac-Serpinb1atm1.1Cben
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpinb1atm1.1Cben mutation (2 available); any Serpinb1a mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 2- to 10-fold less mice survive than wild-type controls when infected intranasaly with P. aeruginosa

immune system
• about 60% less neutrophils in the lungs of mutant mice 24 hours after infection with P. aeruginosa
• about a 2-fold increase in apoptotic neutrophils occurs in the lungs of mutant mice 24 hours after infection with P. aeruginosa
• increased apoptosis leads to more than 2-fold increases in levels of neutrophil fragments and myeloperoxidase in lung fluid
• there is about a 3-fold increase in both apoptosis and necrosis of neutrophils when cultured in vitro for 24 hours
• neutrophil numbers are comparable to wild-type when inflammation is driven by LPS
• circulating levels of CSF3 (G-CSF) are almost 2 times higher in mutant mice 24 hours after infection with P. aeruginosa
• about a 3-fold increase in CXCL-1 (KC) levels found in bronchoalveolar fluid of mutant mice 24 hours after infection with P. aeruginosa
• about a 5-fold increase in IL-1beta levels found in bronchoalveolar fluid of mutant mice 24 hours after infection with P. aeruginosa
• about a 2.5-fold increase in TNF levels found in bronchoalveolar fluid of mutant mice 24 hours after infection with P. aeruginosa
• numerous bacterial colonies and large areas of alveolar exudates are present in the lungs 24 hours after P. aeruginosa infection
• median bacterial count in the lungs is 3 to 5 log units higher than wild-type controls 24 hours after infection with two different strains of P. aeruginosa
• 2- to 10-fold less mice survive than wild-type controls when infected intranasaly with P. aeruginosa
• 2 log units of P. aeruginosa bacteria are in spleen of mice 24 hours after infection compared to none in wild-type controls

respiratory system
• numerous bacterial colonies and large areas of alveolar exudates are present in the lungs 24 hours after P. aeruginosa infection
• 24 hours after P. aeruginosa infection, homozygotes display a significant reduction in pulmonary surfactant protein-D levels due to increased proteolytic activity

hematopoietic system
• about 60% less neutrophils in the lungs of mutant mice 24 hours after infection with P. aeruginosa
• about a 2-fold increase in apoptotic neutrophils occurs in the lungs of mutant mice 24 hours after infection with P. aeruginosa
• increased apoptosis leads to more than 2-fold increases in levels of neutrophil fragments and myeloperoxidase in lung fluid
• there is about a 3-fold increase in both apoptosis and necrosis of neutrophils when cultured in vitro for 24 hours
• neutrophil numbers are comparable to wild-type when inflammation is driven by LPS

homeostasis/metabolism
• circulating levels of CSF3 (G-CSF) are almost 2 times higher in mutant mice 24 hours after infection with P. aeruginosa

cellular
• neutrophil numbers are comparable to wild-type when inflammation is driven by LPS


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory