Phenotypes Associated with This Genotype

Genotype
MGI:3761616

• Allelic Composition: Il22^tm1Flv/Il22^tm1Flv
• Genetic Background: B6.Cg-Il22^tm1Flv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to endotoxin shock ( J:126103 )

• following injection concanavalin, 32% (at 10 ug/g) and 100% (at 20 ug/g) of mice die whereas no wild-type mice exhibit any outward signs of morbidity

• however, mice have normal innate and adaptive immune responses to Listeria monocytogenes infection

liver inflammation ( J:126103 )

• mice exhibit more extensive liver damage in response to concanavalin-mediated hepatitis

• however, suppression of IFN-gamma-induced inflammation abolishes the excessive liver damage

homeostasis/metabolism

increased circulating alanine transaminase level ( J:126103 )

• following injection of concanavalin

• however, levels are normal following injection of phosphate buffered saline

increased circulating aspartate transaminase level ( J:126103 )

• following injection of concanavalin

• however, levels are normal following injection of phosphate buffered saline

increased physiological sensitivity to xenobiotic ( J:126103 )

• following injection of concanavalin, mice develop more lesions than wild-type mice and extensive lesions on the perimeter of the liver lobes

• however, suppression of IFN-gamma-induced inflammation abolishes the excessive liver damage

liver/biliary system

liver inflammation ( J:126103 )

• mice exhibit more extensive liver damage in response to concanavalin-mediated hepatitis

• however, suppression of IFN-gamma-induced inflammation abolishes the excessive liver damage