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Phenotypes Associated with This Genotype
Genotype
MGI:3761175
Allelic
Composition
Tg(MMTV-neu/OT-I/OT-II)CBnel/?
Tg(Trp53R172H)8512Jmr/?
Genetic
Background
involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-neu/OT-I/OT-II)CBnel mutation (1 available)
Tg(Trp53R172H)8512Jmr mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors
• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

integument
• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors
• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

tumorigenesis
• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors
• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:122846


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory