Mouse Genome Informatics
cx
    Tg(MMTV-neu/OT-I/OT-II)CBnel/?
Tg(Trp53R172H)8512Jmr/?

involves: C57BL/6 * FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors
• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:122846