Mouse Genome Informatics
tg
    Tg(MMTV-neu/OT-I/OT-II)CBnel/?
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• only ~50% of females develop mammary tumors by 16 months of age
• ~37% of mammary tumor-bearing mice frequently have lung metastases consisting of >1mm tumor cell emboli growing within blood vessels

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:122846