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Phenotypes Associated with This Genotype
Genotype
MGI:3761174
Allelic
Composition
Tg(MMTV-neu/OT-I/OT-II)CBnel/?
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-neu/OT-I/OT-II)CBnel mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• only ~50% of females develop mammary tumors by 16 months of age
• ~37% of mammary tumor-bearing mice frequently have lung metastases consisting of >1mm tumor cell emboli growing within blood vessels

endocrine/exocrine glands
• only ~50% of females develop mammary tumors by 16 months of age

integument
• only ~50% of females develop mammary tumors by 16 months of age

respiratory system
• ~37% of mammary tumor-bearing mice frequently have lung metastases consisting of >1mm tumor cell emboli growing within blood vessels

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:122846


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory