Phenotypes for Hrh1 MGI:3761138 MGI Mouse

increased brown adipose tissue amount ( J:107191 )

• the amount of brown adipose tissue at 48 weeks of age is increased relative to in wild-type mice

• insulin levels during a 4 week feeding schedule are lower than in mice fed ad libitum

• however, the levels of brown adipose tissue at 12 weeks of age is normal

increased white adipose tissue amount ( J:107191 )

• at 28 weeks of age, white adipose tissue is increased by 23%, 48% and 40% in the epididymmal, mesenteric and retroperitoneal fat pads, respectively, compared to wild-type mice

decreased total body fat amount ( J:107191 )

• unlike in wild-type mice, intraperitoneal administration of the histamine agonist methyl(2[2-pyridyl]ethyl)amine dyhydrochloride (1 ug/g for 7 days) results in decreased in adiposity

increased fat cell size ( J:107191 )

• adipocytes in the epididymal white adipose tissue are larger than in wild-type mice at 48 weeks of age

• however, adipocyte size at 12 weeks of age is normal

increased skeletal muscle triglyceride level ( J:107191 )

• mice exhibit 20% more triglycerides in skeletal muscle compared to wild-type mice

decreased circulating insulin level ( J:107191 )

• at 48 weeks of age, serum insulin levels are increased relative to in wild-type mice

• however, at 12 weeks of age serum insulin levels are normal

increased circulating leptin level ( J:107191 )

• at 48 weeks of age, leptin levels are increased by 66% compared to in wild-type mice

• however, at 12 weeks of age leptin levels are normal

increased circulating free fatty acids level ( J:107191 )

• at 48 weeks of age, free fatty acid levels are increased relative to in wild-type mice

• however, at 12 weeks of age free fatty acid levels are normal

increased liver triglyceride level ( J:107191 )

• mice exhibit 45% more triglycerides in the liver compared to wild-type mice

increased skeletal muscle triglyceride level ( J:107191 )

• mice exhibit 20% more triglycerides in skeletal muscle compared to wild-type mice

abnormal response/metabolism to endogenous compounds ( J:107191 )

• following intracerebroventricular administration of 0.5 ug leptin or intraperitoneal injection of 50 ug of leptin, mice exhibit a smaller decrease in food consumption and body mass relative to wild-type

abnormal circadian feeding behavior ( J:107191 )

• at 48 weeks, the ratio of food consumed in the light versus dark phase is smaller than in wild-type mice

decreased food intake ( J:107191 )

• unlike in wild-type mice, intraperitoneal administration of the histamine agonist methyl(2[2-pyridyl]ethyl)amine dyhydrochloride (1 ug/g for 7 days) results in decreased food intake

• however, intracerebroventricular administration of methyl(2[2-pyridyl]ethyl)amine dyhydrochloride has no effect on mice

increased food intake ( J:107191 )

• at 48 weeks of age, mice consume slightly more food than wild-type mice

• however, at 12 weeks of age food consumption is normal

decreased body weight ( J:107191 )

• during 4 week on a feeding schedule, mice fail to gain weight as do wild-type mice despite equivalent food consumption

• unlike in wild-type mice, intraperitoneal administration of the histamine agonist methyl(2[2-pyridyl]ethyl)amine dyhydrochloride (1 ug/g for 7 days) results in decreased body mass

• however, intracerebroventricular administration of methyl(2[2-pyridyl]ethyl)amine dyhydrochloride has no effect on mice

increased body weight ( J:107191 )

• after 28 weeks of age mice exhibit increased body mass relative to wild-type mice

increased IgG level ( J:110367 )

• following ovalbumin challenge, IgG1, IgG2a and IgG2b levels are increased relative to similarly treated wild-type mice

increased IgM level ( J:110367 )

• following ovalbumin challenge, IgM levels are increased relative to similarly treated wild-type mice

decreased interferon-gamma secretion ( J:110367 )

• antigen stimulation of splenocytes results in the production of less interferon-gamma compared to in similarly treated wild-type mice

decreased interleukin-13 secretion ( J:110367 )

• antigen stimulation of splenocytes results in the production of less IL-13 compared to in similarly treated wild-type mice

decreased interleukin-5 secretion ( J:110367 )

• antigen stimulation of splenocytes results in the production of less IL-5 compared to in similarly treated wild-type mice

decreased inflammatory response ( J:110367 )

• following challenge with ovalbumin, mice fail to develop lung inflammation as do wild-type mice with fewer eosinophils and lymphocytes detected in the bronchoalveolar lavage

• however, mice exhibit normal B cell immune responses and inhalation of IL-4 or IL-13 induces lung inflammation