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Phenotypes Associated with This Genotype
STOCK Otofdeaf5Jcs/Kjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otofdeaf5Jcs mutation (1 available); any Otof mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• vestibular-evoked potential is normal and movement, righting responses, and swim tests are normal indicating normal vestibular function
• bushy cells from homozygotes fire action potentials to less steeply rising depolarizations than in unaffected controls, miniature excitatory postsynaptic currents are larger and carry more charge than in unaffected controls
• ABR could not be detected in homozygotes at 4 weeks of age (J:125960)

nervous system
• the ventral cochlear nuclei are significantly smaller than normal, volumes reduced by 46%, and that of the dorsal cochlear nuclei did not reach significance
• the auditory nerve is reduced by an average of 54%, the end bulbs of Held and the axons to them are smaller than normal, there are fewer end bulbs and they are thinner and more wispy with fewer branches per end than normal
• distortion product acoustic emissions are normal, but auditory brainstem responses are not, consistent with failed synaptic transmission between cochlear hair cells and spiral ganglion cells


Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive nonsyndromic deafness 9 DOID:0110535 OMIM:601071

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory