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Phenotypes Associated with This Genotype
Genotype
MGI:3760281
Allelic
Composition
Ay/a
Genetic
Background
involves: KK
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (365 available)
Ay mutation (10 available); any a mutation (365 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• blood glucose levels increase with age in both sexes
• marked hyperglycemia (400-500 mg/dl) develops by 16 weeks of age
• markedly elevated plasma immunoreactive insulin (IRI) level increases with age
• present at all ages tested (5, 10, 16 weeks) and in both sexes
• insulin sensitivity is impaired at 10 weeks and lost by 16 weeks
• lipogenesis from acetate is elevated at 5 weeks of age, the enhanced activity is maintained until 16 weeks of age
• the acetate/glucose ratio is higher than control in young mice

adipose tissue
• adipose tissue weight increases with age, reaching a maximum at 10 weeks of age

growth/size/body
• greater body weight gain occurs in females as compared to black KK controls

endocrine/exocrine glands
• islets are hypertrophic in 10-16 week old mice
• central cavity formation with occasional red blood cells is observed in islets
• beta cells are degranulated
• degranulated islets are infiltrated with fine glycogen granules

renal/urinary system
• present at all ages tested (5, 10, 16 weeks) and in both sexes
• basement membrane of Bowman's capsules is thickened
• some glomeruli exhibit an accumulation of eosinophilic material in the outer parts of the capillary
• mesangial matrix is thickened
• basement membrane of tubules is thickened
• hyaline materials or hyaline cast is present in tubules
• hyaline materials or hyaline cast is present in tubules

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:26460


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory