Mouse Genome Informatics
ht
    Ay/a
involves: KK
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• blood glucose levels increase with age in both sexes
• marked hyperglycemia (400-500 mg/dl) develops by 16 weeks of age
• markedly elevated plasma immunoreactive insulin (IRI) level increases with age
• present at all ages tested (5, 10, 16 weeks) and in both sexes
• insulin sensitivity is impaired at 10 weeks and lost by 16 weeks
• lipogenesis from acetate is elevated at 5 weeks of age, the enhanced activity is maintained until 16 weeks of age
• the acetate/glucose ratio is higher than control in young mice

adipose tissue
• adipose tissue weight increases with age, reaching a maximum at 10 weeks of age

growth/size/body
• adipose tissue weight increases with age, reaching a maximum at 10 weeks of age
• greater body weight gain occurs in females as compared to black KK controls

endocrine/exocrine glands
• islets are hypertrophic in 10-16 week old mice
• central cavity formation with occasional red blood cells is observed in islets
• beta cells are degranulated
• degranulated islets are infiltrated with fine glycogen granules

renal/urinary system
• present at all ages tested (5, 10, 16 weeks) and in both sexes
• basement membrane of Bowman's capsules is thickened
• some glomeruli exhibit an accumulation of eosinophilic material in the outer parts of the capillary
• mesangial matrix is thickened
• basement membrane of tubules is thickened
• hyaline materials or hyaline cast is present in tubules
• hyaline materials or hyaline cast is present in tubules

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:26460