Phenotypes for Mapkap1 MGI:3759855 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Mapkap1^tm1Bisu/Mapkap1^tm1Bisu
Genetic Background	B6.129S7-Mapkap1^tm1Bisu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkap1^tm1Bisu mutation (0 available); any Mapkap1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:125618 )

• embryonic lethality occurs due to early developmental problems

cellular

increased cellular sensitivity to hydrogen peroxide ( J:125618 )

• when exposed to hydrogen peroxide mouse embryonic fibroblasts (MEFs) exhibit a 20% to 50% survival rate compared to a 70% to 100% survival rate for wild-type MEFs

increased fibroblast apoptosis ( J:125618 )

• when treated with etoposide, mouse embryonic fibroblasts (MEFs) undergo a 2-fold increase in apoptosis compared to wild-type MEFs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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