Phenotypes Associated with This Genotype

Genotype
MGI:3759064

• Allelic Composition: Hace1^tm1Pngr/Hace1^tm1Pngr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:125183 )

• starting at week 20, mice develop spontaneous tumors as they age including melanomas, hepatocellular carcinomas, spontaneous lung adenocarcinomas, angiosarcomas, mammary carcinomas, lymphomas, sarcomas, and lung and soft tissue tumors

• by 2 years of age, the incidence of spontaneous tumor reaches about 12% compared to 1 to 2% in wild-type and heterozygous mice

increased T cell derived lymphoma incidence ( J:125183 )

• mice treated with a dose of gamma radiation that induces a very low incidence of thymic lymphomas exhibit a 30% incidence with a CD4-CD8-TCRalphabeta^low phenotypemice treated with a dose of gamma radiation that induces a very low incidence of thymic lymphomas exhibit a 30% incidence with a CD4-CD8-TCRalphabeta^low phenotype

increased lung tumor incidence ( J:125183 )

• mice exhibit multifocal, large and rapidly growing lung tumors in response to urethane unlike similarly treated wild-type mice that do not develop lung tumors

respiratory system

increased lung tumor incidence ( J:125183 )

• mice exhibit multifocal, large and rapidly growing lung tumors in response to urethane unlike similarly treated wild-type mice that do not develop lung tumors

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:125183 )

• mice treated with a dose of gamma radiation that induces a very low incidence of thymic lymphomas exhibit a 30% incidence with a CD4-CD8-TCRalphabeta^low phenotypemice treated with a dose of gamma radiation that induces a very low incidence of thymic lymphomas exhibit a 30% incidence with a CD4-CD8-TCRalphabeta^low phenotype