Phenotypes Associated with This Genotype

Genotype
MGI:3758714

• Allelic Composition: Notch1^tm1Agt/Notch1^tm1Agt; Notch2^tm1Frad/Notch2^tm1Frad; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129 * BALB/c * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:125373 )

• irradiated wild-type mice reconstituted with Notch1/2-null bone marrow progenitors analyzed at 8 weeks show block at earliest intrathymic precursor stage; immature B cells develop in the thymus recapitulating the Notch1-null phenotype

• cultured double-null hematopoietic stem cells, HSCs do not develop into T cell progenitors after 10 days

arrested T cell differentiation ( J:125373 )

• cultured double null HSCs display a block at the double negative 1 stage

immune system

abnormal T cell differentiation ( J:125373 )

• irradiated wild-type mice reconstituted with Notch1/2-null bone marrow progenitors analyzed at 8 weeks show block at earliest intrathymic precursor stage; immature B cells develop in the thymus recapitulating the Notch1-null phenotype

• cultured double-null hematopoietic stem cells, HSCs do not develop into T cell progenitors after 10 days

arrested T cell differentiation ( J:125373 )

• cultured double null HSCs display a block at the double negative 1 stage