Phenotypes Associated with This Genotype

Genotype
MGI:3758422

• Allelic Composition: Cnr1^tm1Map/Cnr1^tm1Map
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:109213 )

• following middle cerebral artery occlusion (MCA), mice exhibit a 5-fold increase in mortality compared with similarly treated wild-type mice

behavior/neurological

impaired behavioral response to addictive substance ( J:52188 )

• unlike in wild-type mice, there is no decrease in horizontal locomotor activity or rectal temperature following treatment with delta9-tetrahydrocannabinol (delta9-THC)

• in an intravenous self-administration model, the number of nose pokes leading to WIN55,212-2 administration are reduced compared to wild-type mice

• unlike in wild-type mice, there is no abstinence when treated with the Cnr1-receptor antagonist SR141.716A following long term exposure to delta-THC

• unlike wild-type mice, there is no hypotensive response to anandamide or WIN55,212-2

impaired behavioral response to morphine ( J:52188 )

• in an intravenous self-administration model, the number of nose pokes leading to morphine administration are reduced compared to wild-type mice

• naloxine-precipitated morphine withdrawal symptoms are decreased compared to in wild-type mice

abnormal active avoidance behavior ( J:103942 )

• in an active avoidance test, mice exhibit increased conditioned responses compared with wild-type mice

impaired conditioned place preference behavior ( J:52188 )

• the dysphoric effect on conditioned place aversion by U-50,488H is not observed in mutant mice

increased exploration in new environment ( J:52188 )

• when newly exposed to the arena, mice exhibit a moderate increase in locomotor activity to 119% of wild-type mice

• mice exhibit increased exploratory behavior under stressful conditions of an open field and in the spontaneous alteration test (58.9+/-2.2 visits to the arms compared to 47.2+/-1.6 visits to the arms for wild-type mice)

• mice exhibit a decrease in spontaneous alternations in a Y maze (53.7+/-1.9% compared to 61.4+/-1.8% for wild-type mice)

• however, the number of entries and time spent in the open arms in an elevated plus maze are normal

abnormal depression-related behavior ( J:103942 )

• in response to chronic unpredictable mild stress, mice exhibit increased depressive-like behavior compared with wild-type mice

anhedonia ( J:103942 )

• in response to chronic unpredictable mild stress, mice exhibit increased depressive-like behavior compared with wild-type mice

increased anxiety-related response ( J:89437 , J:89722 , J:103942 )

• in an elevated plus maze, mice spend less time exploring open arms compared with wild-type mice (J:89437)

• however, mice treated with the cannabinoid antagonist SR141716A exhibit a normal reduction in anxiety (J:89437)

• under high light conditions, mice exhibit increased anxiety-related behavior in an elevated plus maze compared with wild-type mice (J:89722)

• however, behavior in an elevated plus maze under low light conditions is normal (J:89722)

• in a light/dark box (J:103942)

abnormal response to novel object ( J:52188 )

• time spent exploring an unknown object is increased (5.33+/-1.5 s compared to 0.66+/-0.3 s for wild-type mice)

hyperactivity ( J:52188 )

• when newly exposed to the arena, mice exhibit a moderate increase in locomotor activity to 119% of wild-type mice

• however, activity levels are normal after habituation

increased locomotor activity ( J:52188 )

• the antinociception effect of delta9-tetrahydrocannabinol (THC) is abolished when mice are subjected to a hot-plate test and strongly reduced when subjected to a tail-immersion test

• however, the antinociceptive effect of morphine and U-50,488H and the tolerance development for morphine are unaltered

abnormal social/conspecific interaction behavior ( J:89722 )

• in an unfamiliar cage, mice exhibit decreased social interaction compared with wild-type mice

increased aggression towards mice ( J:89722 , J:103942 )

• mice exhibit increased aggression towards other mice in a home cage compared with wild-type mice (J:89722)

• in a resident-intruder test (J:103942)

nervous system

increased susceptibility to neuronal excitotoxicity ( J:109213 )

• lesions induced by NMDA are twice as large as in similarly treated wild-type mice

abnormal neuronal precursor proliferation ( J:102006 )

• neuronal precursor cell proliferation in the dorsal ganglion and subventricular zone (SVZ) is decreased 50% compared to in wild-type mice

• SR141716A increases proliferation in the dorsal ganglion to a greater extent than in similarly treated wild-type mice

• AM251 induces proliferation in the dorsal ganglion and SVZ unlike in similarly treated wild-type mice

increased susceptibility to ischemic brain injury ( J:109213 )

• ollowing middle cerebral artery occlusion (MCA), mice exhibit a 5-fold increase in mortality compared with similarly treated wild-type mice

increased cerebral infarct size ( J:109213 )

• following middle cerebral artery occlusion (MCA)

homeostasis/metabolism

increased circulating adrenocorticotropin level ( J:89722 )

• basal and stress-induced

increased physiological sensitivity to xenobiotic ( J:172874 )

• slightly but significantly more sensitive to 3NP intoxication

increased susceptibility to neuronal excitotoxicity ( J:109213 )

• lesions induced by NMDA are twice as large as in similarly treated wild-type mice

increased susceptibility to ischemic brain injury ( J:109213 )

• ollowing middle cerebral artery occlusion (MCA), mice exhibit a 5-fold increase in mortality compared with similarly treated wild-type mice

increased cerebral infarct size ( J:109213 )

• following middle cerebral artery occlusion (MCA)

cellular

increased susceptibility to neuronal excitotoxicity ( J:109213 )

• lesions induced by NMDA are twice as large as in similarly treated wild-type mice

abnormal neuronal precursor proliferation ( J:102006 )

• neuronal precursor cell proliferation in the dorsal ganglion and subventricular zone (SVZ) is decreased 50% compared to in wild-type mice

• SR141716A increases proliferation in the dorsal ganglion to a greater extent than in similarly treated wild-type mice

• AM251 induces proliferation in the dorsal ganglion and SVZ unlike in similarly treated wild-type mice