Analysis Tools
nervous system
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• 30 mg/kg kainic acid induces stronger seizures than in wild-type mice
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• misrouted thalamocortical axons (TCAs) are observed in mutants but not in controls, similar to the complete Cnr1tm1.1Ltz total null animals at E16.5
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• deficits in fasciculation at E16.5 are similar to those observed in Cnr1tm1.1Ltz total null animals at E16.5
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behavior/neurological
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• 30 mg/kg kainic acid induces stronger seizures than in wild-type mice
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• mutants eat less than controls on the first day of a novel palatable food test, however they progressively increase their palatable food consumption over the next 4 days to a similar level as in controls
• mutants display a very limited physical interaction with a novel object, when the palatability component is removed
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• mutants take more time to approach and eat novel food on the first exposure compared to wild-type mice, indicating increased behavioral inhibition in the approach of novel palatable food
• mutants exhibit an increase in both the latencies of contact with the novel food item and to displace the novel object
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cellular
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• deficits in fasciculation at E16.5 are similar to those observed in Cnr1tm1.1Ltz total null animals at E16.5
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