About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3758089
Allelic
Composition
Tg(Camk2a-DISC1)10Asaw/0
Genetic
Background
C57BL/6-Tg(Camk2a-DISC1)10Asaw
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• baseline extracellular dopamine is decreased in the ventral striatum
• at 6 weeks, the lateral ventricles are enlarged in volume
• at 6 weeks, the normal asymmetry between the left and right lateral ventricles is lost or even reversed
• at 6 weeks, occurrences of left side ventricle enlargement are increased
• at 6 weeks, significant changes in the left-right ratio are observed in the hippocampus but not the cortex or basal ganglia
• increase in left ventricle size is correlated with shrinkage of brain structures on the same side
• T2-weighted right value for the thalamus is increased compared to in wild-type mice
• T2-weighted right value for the thalamus is increased compared to in wild-type mice
• at 6 weeks, significant changes in the left-right ratio are observed in the hippocampus but not the cortex or basal ganglia
• when prepulse is 74 dB, prepulse inhibition is reduced compared to in wild-type mice

behavior/neurological
• mice take longer to find hidden food pellets
• however, mice do not display anxiety-associated behaviors, and exhibit normal spatial learning and memory in the Morris water maze, working memory in a Y-maze, and social interactions
• mutants exhibit increased sensitivity to metamphetamine, showing a greater augmentation in locomotion compared to wild-type littermates
• mice exhibit immobility when forced to swim
• mice places in an open field for 2 hours exhibit hyperactivity predominantly in the second hour

homeostasis/metabolism
• baseline extracellular dopamine is decreased in the ventral striatum
• mutants exhibit increased sensitivity to metamphetamine, showing a higher increase in extracellular dopamine in the ventral striatum compared to wild-type littermates

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia 9; SCZD9 604906 J:194985
Schizophrenia; SCZD 181500 J:124683


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory