Mouse Genome Informatics
ht
    Ndntm1.1Mus/Ndn+
involves: 129S2/SvPas * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• the number of hypothalamic oxytocin- and luteinizing hormone-releasing hormone-producing neurons is decreased in paternal-deficient heterozygous mice
• paternal-deficient mice showed no gross morphological abnormalities
• general histological makers revealed no obvious differences in brain structure in paternal-deficient heterozygous mice

behavior/neurological
• skin scraping was significantly increased in paternal-deficient mice
• spatial learning assessed in the Morris water maze test show improved ability of the mutant to remember accurately the location of the platform in paternal-deficient heterozygous mice

Mouse Models of Human Disease
OMIM IDRef(s)
Prader-Willi Syndrome; PWS 176270 J:66557