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Phenotypes Associated with This Genotype
Genotype
MGI:3723649
Allelic
Composition
Ndntm1.1Mus/Ndn+
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndntm1.1Mus mutation (0 available); any Ndn mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the number of hypothalamic oxytocin- and luteinizing hormone-releasing hormone-producing neurons is decreased in paternal-deficient heterozygous mice
• paternal-deficient mice showed no gross morphological abnormalities
• general histological makers revealed no obvious differences in brain structure in paternal-deficient heterozygous mice

behavior/neurological
• spatial learning assessed in the Morris water maze test show improved ability of the mutant to remember accurately the location of the platform in paternal-deficient heterozygous mice
• skin scraping was significantly increased in paternal-deficient mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Prader-Willi Syndrome; PWS 176270 J:66557


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory