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Phenotypes Associated with This Genotype
Genotype
MGI:3723137
Allelic
Composition
Bchetm1Loc/Bchetm1Loc
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bchetm1Loc mutation (2 available); any Bche mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• donepezil-treated mice die within 3 hours unlike similarly treated controls
• (-)-huperzin A-treated mice die within 10 minutes unlike similarly treated controls

reproductive system
N
• mice are fertile

homeostasis/metabolism
• donepezil-treated mice die within 3 hours unlike similarly treated controls
• (-)-huperzin A-treated mice die within 10 minutes unlike similarly treated controls
• treatment with donepezil induces clonic, jerking convulsions and death within 3 hours unlike similarly treated wild-type mice that recover within 24 hours
• (-)-huperzin A-treated mice exhibit protosis, salivation, and lacrimation with death occurring within 10 minutes of treatment unlike similarly treated mice
• however, mice exhibit a normal reaction to CPO and echothiophate


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory