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Phenotypes Associated with This Genotype
Genotype
MGI:3723137
Allelic
Composition
Bchetm1Loc/Bchetm1Loc
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bchetm1Loc mutation (2 available); any Bche mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• donepezil-treated mice die within 3 hours unlike similarly treated controls (J:130048)
• (-)-huperzin A-treated mice die within 10 minutes unlike similarly treated controls (J:130048)
• donepezil-treated mice die within 3 hours unlike similarly treated controls (J:130048)
• (-)-huperzin A-treated mice die within 10 minutes unlike similarly treated controls (J:130048)

reproductive system
N
• mice are fertile (J:124975)
• mice are fertile (J:124975)

homeostasis/metabolism
• donepezil-treated mice die within 3 hours unlike similarly treated controls (J:130048)
• (-)-huperzin A-treated mice die within 10 minutes unlike similarly treated controls (J:130048)
• donepezil-treated mice die within 3 hours unlike similarly treated controls (J:130048)
• (-)-huperzin A-treated mice die within 10 minutes unlike similarly treated controls (J:130048)
• treatment with donepezil induces clonic, jerking convulsions and death within 3 hours unlike similarly treated wild-type mice that recover within 24 hours (J:130048)
• (-)-huperzin A-treated mice exhibit protosis, salivation, and lacrimation with death occurring within 10 minutes of treatment unlike similarly treated mice (J:130048)
• however, mice exhibit a normal reaction to CPO and echothiophate (J:130048)
• however, mice exhibit a normal reaction to CPO and echothiophate (J:130048)
• treatment with donepezil induces clonic, jerking convulsions and death within 3 hours unlike similarly treated wild-type mice that recover within 24 hours (J:130048)
• (-)-huperzin A-treated mice exhibit protosis, salivation, and lacrimation with death occurring within 10 minutes of treatment unlike similarly treated mice (J:130048)

Mouse Models of Human Disease
OMIM ID Ref(s)
Butyrylcholinesterase; BCHE 177400 J:130048


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory