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Phenotypes Associated with This Genotype
Genotype
MGI:3723137
Allelic
Composition
Bchetm1Loc/Bchetm1Loc
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bchetm1Loc mutation (2 available); any Bche mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• donepezil-treated mice die within 3 hours unlike similarly treated controls
• (-)-huperzin A-treated mice die within 10 minutes unlike similarly treated controls

reproductive system
N
• mice are fertile

homeostasis/metabolism
• donepezil-treated mice die within 3 hours unlike similarly treated controls
• (-)-huperzin A-treated mice die within 10 minutes unlike similarly treated controls
• treatment with donepezil induces clonic, jerking convulsions and death within 3 hours unlike similarly treated wild-type mice that recover within 24 hours
• (-)-huperzin A-treated mice exhibit protosis, salivation, and lacrimation with death occurring within 10 minutes of treatment unlike similarly treated mice
• however, mice exhibit a normal reaction to CPO and echothiophate

Mouse Models of Human Disease
OMIM ID Ref(s)
Butyrylcholinesterase; BCHE 177400 J:130048


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory