Mouse Genome Informatics
hm
    Bchetm1Loc/Bchetm1Loc
involves: 129S1/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• donepezil-treated mice die within 3 hours unlike similarly treated controls
• (-)-huperzin A-treated mice die within 10 minutes unlike similarly treated controls

reproductive system
N
• mice are fertile (J:124975)

homeostasis/metabolism
• donepezil-treated mice die within 3 hours unlike similarly treated controls
• (-)-huperzin A-treated mice die within 10 minutes unlike similarly treated controls
• treatment with donepezil induces clonic, jerking convulsions and death within 3 hours unlike similarly treated wild-type mice that recover within 24 hours
• (-)-huperzin A-treated mice exhibit protosis, salivation, and lacrimation with death occurring within 10 minutes of treatment unlike similarly treated mice
• however, mice exhibit a normal reaction to CPO and echothiophate

Mouse Models of Human Disease
OMIM IDRef(s)
Butyrylcholinesterase; BCHE 177400 J:130048