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Phenotypes Associated with This Genotype
Genotype
MGI:3723060
Allelic
Composition
P2ry12tm1Cjf/P2ry12tm1Cjf
Genetic
Background
involves: 129/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2ry12tm1Cjf mutation (0 available); any P2ry12 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• platelets aggregate poorly in response to ADP and display a reduced sensitivity to thrombin and collagen; platelets retain normal shape change and calcium influx in response to ADP but fail to inhibit adenylyl cyclase

homeostasis/metabolism
• platelets aggregate poorly in response to ADP and display a reduced sensitivity to thrombin and collagen; platelets retain normal shape change and calcium influx in response to ADP but fail to inhibit adenylyl cyclase
• mutants display prolonged bleeding times (more than 30 min vs. 3.5 min in wild-type)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
platelet-type bleeding disorder 8 DOID:0060692 OMIM:609821
J:70017


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory