Phenotypes Associated with This Genotype

Genotype
MGI:3722833

• Allelic Composition: Elovl4^tm1Kzh/Elovl4^tm1Kzh
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:161118 )

growth/size/body

weight loss ( J:161118 )

• pups removed from their mothers at E19 loose 3% of body weight within 30 minutes

• weight loss of 15% of body weight within 5 hours

decreased fetal size ( J:124499 )

• at E18, mice are smaller than wild-type or heterozygote littermates

decreased fetal weight ( J:124499 )

• at E18, mice weigh about 13% less than wild-type or heterozygote littermates

limbs/digits/tail

short forelimb ( J:124499 )

• forelimbs shortened at E18

hematopoietic system

abnormal erythrocyte morphology ( J:124499 )

• red blood cell membranes contain higher levels poly-unsaturated fatty acids including docosahexaenoic acid (DHA) but lower levels of eicosapentaenoic acid a precursor to DHA

homeostasis/metabolism

impaired skin barrier function ( J:161118 )

• E19 homozygotes absorb toluidine blue unlike controls

integument

impaired skin barrier function ( J:161118 )

• E19 homozygotes absorb toluidine blue unlike controls

abnormal epidermis stratum corneum morphology ( J:161118 )

• very thin and fragile

abnormal skin appearance ( J:161118 )

shiny skin ( J:161118 )

• at E19

abnormal skin condition ( J:161118 )

• very long chain fatty acids, with more than 26 carbons are reduced in the skin

• there is a build up of 26 carbon fatty acids

thin skin ( J:161118 )

• at E19

• dermis-epidermis x-section is only 70% of normal thickness