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Phenotypes Associated with This Genotype
Genotype
MGI:3722277
Allelic
Composition
Tg(YAC72)2511Hay/?
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(YAC72)2511Hay mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• nuclear translocation of the N-terminal portion of HD is observed in striatal neurons of 12 month old mice with an immunoreactive antibody (EM48) (J:55405)
• nuclear translocation of the N-terminal portion of HD is observed in striatal neurons of 12 month old mice with an immunoreactive antibody (EM48) (J:55405)
• selective degeneration is observed in the striatum at 12 months of age (J:55405)
• neurons are shrunken and hyperchromatic (J:55405)
• selective degeneration is observed in the striatum at 12 months of age (J:55405)
• neurons are shrunken and hyperchromatic (J:55405)
• hippocampal slices from 6 month old mice display a hyperexcitability exhibited as a broad EPSP at the distal dendrites (J:55405)
• hippocampal slices from 6 month old mice display a hyperexcitability exhibited as a broad EPSP at the distal dendrites (J:55405)
• fast synaptic response in these mice has a prominent NMDA component (J:55405)
• fast synaptic response in these mice has a prominent NMDA component (J:55405)
• following tetanization most slices from 6 month old mice exhibit a greater short-term potentiation when compared to controls (J:55405)
• following tetanization most slices from 6 month old mice exhibit a greater short-term potentiation when compared to controls (J:55405)
• by 10 months of age, LTP is not induced in CA1 neurons; high frequency stimulation induces depression instead of potentiation (J:55405)
• by 10 months of age, LTP is not induced in CA1 neurons; high frequency stimulation induces depression instead of potentiation (J:55405)

behavior/neurological
• progressive hyperactivity is observed in the dark phase of open field testing beginning at 7 months of age (J:55405)
• progressive hyperactivity is observed in the dark phase of open field testing beginning at 7 months of age (J:55405)
• circling was observed in one mouse at 8.5 months of age (J:55405)
• circling was observed in one mouse at 8.5 months of age (J:55405)

Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:55405


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory