Mouse Genome Informatics
tg
    Tg(YAC72)2511Hay/?
involves: FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• nuclear translocation of the N-terminal portion of HD is observed in striatal neurons of 12 month old mice with an immunoreactive antibody (EM48)
• selective degeneration is observed in the striatum at 12 months of age
• neurons are shrunken and hyperchromatic
• hippocampal slices from 6 month old mice display a hyperexcitability exhibited as a broad EPSP at the distal dendrites
• fast synaptic response in these mice has a prominent NMDA component
• following tetanization most slices from 6 month old mice exhibit a greater short-term potentiation when compared to controls
• by 10 months of age, LTP is not induced in CA1 neurons; high frequency stimulation induces depression instead of potentiation

behavior/neurological
• progressive hyperactivity is observed in the dark phase of open field testing beginning at 7 months of age
• circling was observed in one mouse at 8.5 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Huntington Disease; HD 143100 J:55405