Analysis Tools
hematopoietic system
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• protection from thrombosis in a pulmonary thromboembolism model in which platelet activation was induced by tail vein infusion of collagen and epinephrin
• the lungs of these mutant mice were largely devoid of platelet thrombi
• protection from thrombosis in a model of arterial thrombosis initiated by vascular injury in response to ferric chloride-induced injury of the common carotid artery
• the mutant mice had no occlusion during the 30 minutes following ferric chloride-induced endothelial damage
• profoundly impaired agonist-induced activation of platelet in vitro
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homeostasis/metabolism
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• protection from thrombosis in a pulmonary thromboembolism model in which platelet activation was induced by tail vein infusion of collagen and epinephrin
• the lungs of these mutant mice were largely devoid of platelet thrombi
• protection from thrombosis in a model of arterial thrombosis initiated by vascular injury in response to ferric chloride-induced injury of the common carotid artery
• the mutant mice had no occlusion during the 30 minutes following ferric chloride-induced endothelial damage
• profoundly impaired agonist-induced activation of platelet in vitro
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• there is more than a 3-fold reduction in thrombus volume formed by mutant platelets on a collagen coated surface
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• impaired hemostasis as evidenced by failure to arrest bleeding within 10 minutes following tail resection
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cardiovascular system
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• small number (1 of 23) of animal showing detectable blood in their stool
• the number is fewer than that of Itgb3tm1Hyn (11 of 11) or that of Itgb3tm1Mgin (19 of 36)
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digestive/alimentary system
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• small number (1 of 23) of animal showing detectable blood in their stool
• the number is fewer than that of Itgb3tm1Hyn (11 of 11) or that of Itgb3tm1Mgin (19 of 36)
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