About   Help   FAQ
Due to maintenance, access to MGI may be intermittent 8:00 AM ET Wed, September 18.
Phenotypes Associated with This Genotype
Genotype
MGI:3721145
Allelic
Composition
Prkcitm1Rfar/Prkci+
Tg(Ckmm-cre)5Khn/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcitm1Rfar mutation (0 available); any Prkci mutation (54 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• males and females have more serum lipid than wild-type mice
• serum free fatty acid levels are increased by 90% relative to wild-type mice
• fasting triglyceride levels are increased relative to in wild-type mice
• in a euglycemic clamp assay, mice require a reduced rate of glucose infusion compared to wild-type mice to maintain euglycemia
• in mice fed ad libitum, serum glucose levels are increased
• fasting glucose levels during insulin and glucose tolerance tests is increased by 20% to 25%
• when dietary fat content is increased from 5% to 10% for 2 months, mice exhibit higher glucose levels than in wild-type mice at all time points and during fasting glucose tolerance testing
• in mice fed ad libitum, serum insulin levels are increased
• in mice fed ad libitum, glucose tolerance impairment is comparable to or more severe than in homozygotes
• in mice fed ad libitum, insulin tolerance is impairment is comparable to or more severe than in homozygotes
• in a euglycemic clamp assay, whole-body insulin resistance is accounted for by decreases in insulin-stimulated whole-body glucose uptake and muscle glucose uptake of 25% and 30%, respectively

cardiovascular system

muscle
• insulin-stimulated uptake of glucose and [3H]2-deoxyglucose in vastus laterallis, soleus and extensor digitorum longus, and heart muscles is reduced by 50% to 60% compared to in wild-type mice

liver/biliary system
• even on a low-fat diet, hepatostetosis occurs and is more pronounced in heterogyzotes than in homozygotes

adipose tissue
• insulin-stimulated glucose transport is impaired

growth/size/body
• body weight is increased relative to wild-type mice and homozygous mice
• mice develop an obesity/diabetes syndrome associated with increased food intake

behavior/neurological
• mice consume 20% more regular chow than wild-type mice

immune system
• mice develop an obesity/diabetes syndrome associated with increased food intake

endocrine/exocrine glands

cellular
• insulin-stimulated glucose transport is impaired
• insulin-stimulated uptake of glucose and [3H]2-deoxyglucose in vastus laterallis, soleus and extensor digitorum longus, and heart muscles is reduced by 50% to 60% compared to in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/10/2019
MGI 6.14
The Jackson Laboratory