Phenotypes Associated with This Genotype

Genotype
MGI:3721114

• Allelic Composition: Cdk5^tm1Bibb/Cdk5^tm1Bibb; Tg(Prnp-cre/ERT)28.4Ics/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal synaptic plasticity ( J:124046 )

• synaptic plasticity is enhanced

abnormal excitatory postsynaptic currents ( J:124046 )

• following treatment with tamoxifen, the ratio of NMDA/AMP excitatory postsynaptic currents (EPSCs) is increased 1.4+/-0.2-fold relative to in wild-type mice

• following treatment with tamoxifen, ifenprodil-sensitive EPSC charges are 3.2+/-0.5-fold more sensitive to ifenprodil and the decay time is longer compared to in wild-type mice

abnormal excitatory postsynaptic potential ( J:124046 )

• following treatment with tamoxifen, field excitatory postsynaptic potential (fEPSP) is stimulated by low theta-burst stimulus that had no affect on wild-type mice

• following treatment with tamoxifen, NMDAR-mediated fEPSPs are increased relative to in wild-type mice and the ratio of NMDAR to AMPA fEPSP is 9.0+/-2.4-fold larger than in wild-type mice

abnormal long-term potentiation ( J:124046 )

• following treatment with tamoxifen, the induction threshold for long term potential is reduced but is reversed with ifenprodil treatment

increased post-tetanic potentiation ( J:124046 )

• following treatment with tamoxifen, a stronger theta-burst that elicits a long term potential in wild-type mice elevates post-tetanic potential in mice compared to wild-type mice

behavior/neurological

abnormal contextual conditioning behavior ( J:124046 )

• following treatment with tamoxifen, mice exhibit increased freezing when re-exposed to context at 24 hours

• following treatment with tamoxifen, less freezing is observed on the fourth exposure at 96 hours after training compared to wild-type mice

abnormal spatial learning ( J:124046 )

• following treatment with tamoxifen, when platform position in a water maze is reversed, mice exhibit shortened escape latency

• following treatment with tamoxifen, mice show improved performance in a reversal special learning task