Phenotypes Associated with This Genotype

Genotype
MGI:3720976

• Allelic Composition: Bmal1^tm1Weit/Bmal1^tm1Weit; Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal eye electrophysiology ( J:124157 )

• under dark-adapted conditions, amplitude of b-wave is reduced by 27%, causing significant reduction in b-wave to a-wave amplitude ratio

• under light-adapted conditions, b-wave amplitude is reduced by 44%

• no detectable circadian rhythm of b-wave amplitude is observed, with b-wave responses apparently fixed at low amplitude at times of both high and low b-wave amplitude (circadian times CT 6 and CT 18)

• no circadian rhythm of b-wave implicit time (time between light stimulus and peak of b-wave) is detectable, whereas this is robust in controls