Phenotypes Associated with This Genotype

Genotype
MGI:3720887

• Allelic Composition: Bax^tm1Sjk/Bax^tm1Sjk
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased mature ovarian follicle number ( J:52574 )

♀ • increased number of follicles observed at 42 days of age

♀ • persistence of hundreds of follicles of all developmental stages in aged females (20 to 22 months old)

abnormal ovarian folliculogenesis ( J:52574 )

♀ • reduced incidence of atresia of primordial and primary follicles relative to wild-type

♀ • increased number of follicles observed at 42 days

♀ • follicles persisted in aged females (20 to 22 months old)

nervous system

abnormal dorsal root ganglion morphology ( J:83461 )

• the number of dorsal root ganglia neurons in L4 is increased relative to in wild-type mice

reproductive system

increased mature ovarian follicle number ( J:52574 )

♀ • increased number of follicles observed at 42 days of age

♀ • persistence of hundreds of follicles of all developmental stages in aged females (20 to 22 months old)

abnormal ovarian folliculogenesis ( J:52574 )

♀ • increased number of follicles observed at 42 days

♀ • follicles persisted in aged females (20 to 22 months old)

♀ • reduced incidence of atresia of primordial and primary follicles relative to wild-type

uterus hypertrophy ( J:52574 )

♀ • ovarian steroid-driven uternine hypertrophy is observed in aged females (20 to 22 months old)