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Phenotypes Associated with This Genotype
Genotype
MGI:3720759
Allelic
Composition
Sncatm1Rosl/Sncatm1Rosl
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sncatm1Rosl mutation (3 available); any Snca mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• dopamine content is reduced by 18% in the striatum, however, dopamine content in the ventral midbrain and nucleus accumbens is similar to wild-type
• when exposed to paired electrical stimuli, striatal brain slices (containing dopamine terminals) from homozygous mice exhibit a faster dopamine release recovery as compared to wild-type
• dopamine discharge and reuptake in response to a single electrical pulse or a train of pulses is comparable to wild-type

behavior/neurological
• homozygous mice exhibit an attenuated locomotor response after administration of amphetamine as compared to wild-type
• in the absence of amphetamine, locomotor activity in the open field test is comparable to wild-type

homeostasis/metabolism
• dopamine content is reduced by 18% in the striatum, however, dopamine content in the ventral midbrain and nucleus accumbens is similar to wild-type

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease 1, Autosomal Dominant; PARK1 168601 J:60151


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory