Mouse Genome Informatics
hm
    Sncatm1Rosl/Sncatm1Rosl
involves: 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• dopamine content is reduced by 18% in the striatum, however, dopamine content in the ventral midbrain and nucleus accumbens is similar to wild-type
• when exposed to paired electrical stimuli, striatal brain slices (containing dopamine terminals) from homozygous mice exhibit a faster dopamine release recovery as compared to wild-type
• dopamine discharge and reuptake in response to a single electrical pulse or a train of pulses is comparable to wild-type

behavior/neurological
• homozygous mice exhibit an attenuated locomotor response after administration of amphetamine as compared to wild-type
• in the absence of amphetamine, locomotor activity in the open field test is comparable to wild-type

homeostasis/metabolism
• dopamine content is reduced by 18% in the striatum, however, dopamine content in the ventral midbrain and nucleus accumbens is similar to wild-type

Mouse Models of Human Disease
OMIM IDRef(s)
Parkinson Disease 1, Autosomal Dominant; PARK1 168601 J:60151