Analysis Tools
mortality/aging
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• mice begin to die at 6 months of age due to wasting and diarrhea
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immune system
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• T cells Th1, Th2 and CTL (cytotoxic T lymphocyte) differentiation is enhanced while Th17-cell differentiation is inhibited
• in the experimental autoimmune encephalomyelitis model, the number of IL-17 producing T cells is reduced in animals that do and those that do not develop encephalomyelitis
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• as determined by transplantation experiments, defects in Th17 cell differentiation occur in an autocrine manner
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• T cell activation is enhanced
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• following activation, interferon-gamma levels are increased relative to in control cells
• in the experimental autoimmune encephalomyelitis model, only mice that develop encephalomyelitis produce great amounts of interferon-gamma
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• following activation, IL-4 levels are increased whereas IL-17 levels are decreased relative to in control cells
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• 6 of 8 mice did not develop encephalomyelitis and only 2 showed mild disease compared to controls which all develop severe disease
• the number of IL-17 producing T cells is reduced in animals that do and those that do not develop encephalomyelitis
• only mice that develop encephalomyelitis produce great amounts of interferon-gamma
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• mice present with mononuclear infiltrate in the lungs, parenchyma of the liver, and colon
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• severe colitis is associated with disruption of the crypt architecture, crypt abscess formation and epithelium hyperplasia
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digestive/alimentary system
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• epithelium hyperplasia is associated with colitis
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• disruption of crypt architecture is associated with colitis
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• associated with colitis
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• at 4 to 12 months of age, heavy mononuclear cell infiltrate of the lamina propria and subglandular areas of the colon is detected
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• severe colitis is associated with disruption of the crypt architecture, crypt abscess formation and epithelium hyperplasia
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growth/size/body
liver/biliary system
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• mononuclear cell clusters are detected in the parenchyma of mice with colitis
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renal/urinary system
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• IgG deposits accumulate in the glomeruli
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respiratory system
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• mononuclear cell infiltrate is present in the lungs of mice with colitis
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endocrine/exocrine glands
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• disruption of crypt architecture is associated with colitis
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• associated with colitis
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hematopoietic system
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• T cells Th1, Th2 and CTL (cytotoxic T lymphocyte) differentiation is enhanced while Th17-cell differentiation is inhibited
• in the experimental autoimmune encephalomyelitis model, the number of IL-17 producing T cells is reduced in animals that do and those that do not develop encephalomyelitis
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• as determined by transplantation experiments, defects in Th17 cell differentiation occur in an autocrine manner
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• T cell activation is enhanced
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homeostasis/metabolism
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• following activation, interferon-gamma levels are increased relative to in control cells
• in the experimental autoimmune encephalomyelitis model, only mice that develop encephalomyelitis produce great amounts of interferon-gamma
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• following activation, IL-4 levels are increased whereas IL-17 levels are decreased relative to in control cells
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cellular
