Mouse Genome Informatics
ht
    Hbab3(th)/Hba+
SEC-Hbab3(th)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• many pups die between birth and weaning

hematopoietic system
• at E13.5 - E15.5, eosinophilic inclusions are seen in liver derived erythrocytes
• however, no abnormalities are seen in yolk-sac derived nucleated erythrocytes

growth/size/body
• newborn pups are smaller than wild-type littermates
• reduced in heterozygous adults to 18.77 +/- 0.59g compared to 23.79 +/- 0.39g in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Alpha-Thalassemia 604131 J:6452